ID   TM208_DICDI             Reviewed;         173 AA.
AC   Q54UB0;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Transmembrane protein 208 homolog;
GN   Name=tmem208; ORFNames=DDB_G0281177;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM208 family. {ECO:0000305}.
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DR   EMBL; AAFI02000040; EAL66885.1; -; Genomic_DNA.
DR   RefSeq; XP_640866.1; XM_635774.1.
DR   AlphaFoldDB; Q54UB0; -.
DR   STRING; 44689.DDB0267026; -.
DR   PaxDb; Q54UB0; -.
DR   EnsemblProtists; EAL66885; EAL66885; DDB_G0281177.
DR   GeneID; 8622922; -.
DR   KEGG; ddi:DDB_G0281177; -.
DR   dictyBase; DDB_G0281177; tmem208.
DR   eggNOG; KOG3269; Eukaryota.
DR   HOGENOM; CLU_094308_0_0_1; -.
DR   InParanoid; Q54UB0; -.
DR   OMA; VFMHILA; -.
DR   PhylomeDB; Q54UB0; -.
DR   PRO; PR:Q54UB0; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005773; C:vacuole; IEA:GOC.
DR   GO; GO:0006624; P:vacuolar protein processing; IBA:GO_Central.
DR   InterPro; IPR008506; SND2/TMEM208.
DR   PANTHER; PTHR13505; PTHR13505; 1.
DR   Pfam; PF05620; TMEM208_SND2; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..173
FT                   /note="Transmembrane protein 208 homolog"
FT                   /id="PRO_0000328896"
FT   TRANSMEM        17..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          142..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..173
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   173 AA;  20149 MW;  29FFFFB094C7BA4F CRC64;
     MANSGAKKRK TQNEKELFKV RLIMAAGTIP YILYRVVYHS ETFGGWLWFA YLSLNALNMF
     AYYIITSMCK LTYDNNGELI DGGSDLNQGG MTEYYFDIIY VCCIIQGLGL ISDKCLYLIL
     VIPAFAIFKI WKTFIGPYLA SRNQQQQQPQ EEKSKRREKM EKKQEKQKVK YVK