ID   TM208_MOUSE             Reviewed;         173 AA.
AC   Q9CR96; Q3V2H5; Q8R1F8;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Transmembrane protein 208;
GN   Name=Tmem208;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J; TISSUE=Kidney, Pancreas, and Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May function as a negative regulator of endoplasmic
CC       reticulum-stress induced autophagy. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9CR96-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9CR96-2; Sequence=VSP_032506;
CC   -!- SIMILARITY: Belongs to the TMEM208 family. {ECO:0000305}.
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DR   EMBL; AK002499; BAB22147.1; -; mRNA.
DR   EMBL; AK005662; BAB24174.1; -; mRNA.
DR   EMBL; AK131833; BAE20823.1; -; mRNA.
DR   EMBL; BC024608; AAH24608.1; -; mRNA.
DR   CCDS; CCDS22599.1; -. [Q9CR96-1]
DR   RefSeq; NP_079762.1; NM_025486.2. [Q9CR96-1]
DR   AlphaFoldDB; Q9CR96; -.
DR   BioGRID; 211380; 2.
DR   STRING; 10090.ENSMUSP00000015000; -.
DR   EPD; Q9CR96; -.
DR   MaxQB; Q9CR96; -.
DR   PaxDb; Q9CR96; -.
DR   PRIDE; Q9CR96; -.
DR   ProteomicsDB; 258914; -. [Q9CR96-1]
DR   ProteomicsDB; 258915; -. [Q9CR96-2]
DR   Antibodypedia; 48545; 29 antibodies from 11 providers.
DR   DNASU; 66320; -.
DR   Ensembl; ENSMUST00000015000; ENSMUSP00000015000; ENSMUSG00000014856. [Q9CR96-1]
DR   Ensembl; ENSMUST00000098453; ENSMUSP00000096052; ENSMUSG00000014856. [Q9CR96-2]
DR   GeneID; 66320; -.
DR   KEGG; mmu:66320; -.
DR   UCSC; uc009ncs.2; mouse. [Q9CR96-1]
DR   CTD; 29100; -.
DR   MGI; MGI:1913570; Tmem208.
DR   VEuPathDB; HostDB:ENSMUSG00000014856; -.
DR   eggNOG; KOG3269; Eukaryota.
DR   GeneTree; ENSGT00390000008139; -.
DR   HOGENOM; CLU_094308_3_0_1; -.
DR   InParanoid; Q9CR96; -.
DR   OMA; VFMHILA; -.
DR   OrthoDB; 1407446at2759; -.
DR   PhylomeDB; Q9CR96; -.
DR   TreeFam; TF318118; -.
DR   BioGRID-ORCS; 66320; 20 hits in 74 CRISPR screens.
DR   ChiTaRS; Tmem208; mouse.
DR   PRO; PR:Q9CR96; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q9CR96; protein.
DR   Bgee; ENSMUSG00000014856; Expressed in seminal vesicle and 255 other tissues.
DR   ExpressionAtlas; Q9CR96; baseline and differential.
DR   Genevisible; Q9CR96; MM.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005773; C:vacuole; IEA:GOC.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0006624; P:vacuolar protein processing; IBA:GO_Central.
DR   InterPro; IPR008506; SND2/TMEM208.
DR   PANTHER; PTHR13505; PTHR13505; 1.
DR   Pfam; PF05620; TMEM208_SND2; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Alternative splicing; Autophagy; Endoplasmic reticulum;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..173
FT                   /note="Transmembrane protein 208"
FT                   /id="PRO_0000325968"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BTX3"
FT   VAR_SEQ         101..173
FT                   /note="HLKDVILLTAIVQVLSCFSLYIWSFWLLAPGRALYLLWVNVLGPWFTADSGA
FT                   PAPELNEKRQRRQERRQMKRL -> VGFFSGWILPEHHPPDDPSVSSTVAPASVSARPW
FT                   ARAACFSVSAAATFSRNRALKREACQRWCLTQVQPRVAHMPC (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_032506"
FT   CONFLICT        8
FT                   /note="G -> D (in Ref. 2; AAH24608)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   173 AA;  19624 MW;  0CC3F1F744AAB438 CRC64;
     MAPKGKVGTR GKKQIFEENK ETLKFYLRII LGANAIYCLV TLVFFYSSAS FWAWMALGFS
     LAVYGASYHS MSSMARASFS EDGSLMDGGM DLNMEQGMAE HLKDVILLTA IVQVLSCFSL
     YIWSFWLLAP GRALYLLWVN VLGPWFTADS GAPAPELNEK RQRRQERRQM KRL