ID   TM208_XENLA             Reviewed;         174 AA.
AC   Q0IHJ0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Transmembrane protein 208;
GN   Name=tmem208;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a negative regulator of endoplasmic
CC       reticulum-stress induced autophagy. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM208 family. {ECO:0000305}.
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DR   EMBL; BC123134; AAI23135.1; -; mRNA.
DR   RefSeq; NP_001090304.1; NM_001096835.1.
DR   AlphaFoldDB; Q0IHJ0; -.
DR   DNASU; 779213; -.
DR   GeneID; 779213; -.
DR   KEGG; xla:779213; -.
DR   CTD; 779213; -.
DR   Xenbase; XB-GENE-941120; tmem208.L.
DR   OMA; VFMHILA; -.
DR   OrthoDB; 1407446at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 779213; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   InterPro; IPR008506; SND2/TMEM208.
DR   PANTHER; PTHR13505; PTHR13505; 1.
DR   Pfam; PF05620; TMEM208_SND2; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..174
FT                   /note="Transmembrane protein 208"
FT                   /id="PRO_0000325971"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          151..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   174 AA;  19846 MW;  DA620AF9AAE7AC72 CRC64;
     MAPKGKVGTK GKKQIYEENK ETLSFYLRII LGATVLCGAI NLGVFYSSSN FWTWATLVFS
     GIVYAGAYRS MRSMAQASFS EDGSLLDGGI DLNMEQGMAE HIKDIVLLTA IVQVLSCFSL
     YFWYFWLLAP GRALYLLWVN VLGPWFTADN SSTVPQEQNE KRQRRQERRQ MKRF