TM209_HUMAN
ID TM209_HUMAN Reviewed; 561 AA.
AC Q96SK2; A4D1L1; Q49A50; Q6PF00; Q8NCH3; Q96SL6;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Transmembrane protein 209;
GN Name=TMEM209;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANTS
RP ARG-469 AND ARG-505.
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98 AND SER-248, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-222, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98 AND SER-248, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9; SER-11; SER-201; SER-248
RP AND SER-278, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q96SK2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96SK2-2; Sequence=VSP_033280;
CC Name=3;
CC IsoId=Q96SK2-3; Sequence=VSP_033283;
CC Name=4;
CC IsoId=Q96SK2-4; Sequence=VSP_033281, VSP_033282;
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DR EMBL; AK027678; BAB55289.1; -; mRNA.
DR EMBL; AK027709; BAB55314.1; -; mRNA.
DR EMBL; AK074732; BAC11168.1; -; mRNA.
DR EMBL; CH236950; EAL24094.1; -; Genomic_DNA.
DR EMBL; CH471070; EAW83748.1; -; Genomic_DNA.
DR EMBL; CH471070; EAW83749.1; -; Genomic_DNA.
DR EMBL; BC045618; AAH45618.1; -; mRNA.
DR EMBL; BC057784; AAH57784.1; -; mRNA.
DR CCDS; CCDS47712.1; -. [Q96SK2-1]
DR CCDS; CCDS75661.1; -. [Q96SK2-3]
DR CCDS; CCDS87547.1; -. [Q96SK2-2]
DR RefSeq; NP_001288092.1; NM_001301163.1. [Q96SK2-3]
DR RefSeq; NP_116231.2; NM_032842.3. [Q96SK2-1]
DR RefSeq; XP_005250712.1; XM_005250655.1. [Q96SK2-2]
DR RefSeq; XP_011514948.1; XM_011516646.2.
DR AlphaFoldDB; Q96SK2; -.
DR BioGRID; 124362; 200.
DR IntAct; Q96SK2; 30.
DR MINT; Q96SK2; -.
DR STRING; 9606.ENSP00000380747; -.
DR GlyGen; Q96SK2; 2 sites.
DR iPTMnet; Q96SK2; -.
DR PhosphoSitePlus; Q96SK2; -.
DR BioMuta; TMEM209; -.
DR DMDM; 187663981; -.
DR EPD; Q96SK2; -.
DR jPOST; Q96SK2; -.
DR MassIVE; Q96SK2; -.
DR MaxQB; Q96SK2; -.
DR PaxDb; Q96SK2; -.
DR PeptideAtlas; Q96SK2; -.
DR PRIDE; Q96SK2; -.
DR ProteomicsDB; 78118; -. [Q96SK2-1]
DR ProteomicsDB; 78119; -. [Q96SK2-2]
DR ProteomicsDB; 78120; -. [Q96SK2-3]
DR ProteomicsDB; 78121; -. [Q96SK2-4]
DR Antibodypedia; 32026; 59 antibodies from 19 providers.
DR DNASU; 84928; -.
DR Ensembl; ENST00000397622.7; ENSP00000380747.2; ENSG00000146842.17. [Q96SK2-1]
DR Ensembl; ENST00000462753.5; ENSP00000419697.1; ENSG00000146842.17. [Q96SK2-2]
DR Ensembl; ENST00000473456.5; ENSP00000417258.1; ENSG00000146842.17. [Q96SK2-3]
DR GeneID; 84928; -.
DR KEGG; hsa:84928; -.
DR MANE-Select; ENST00000397622.7; ENSP00000380747.2; NM_032842.4; NP_116231.2.
DR UCSC; uc003vpn.2; human. [Q96SK2-1]
DR CTD; 84928; -.
DR DisGeNET; 84928; -.
DR GeneCards; TMEM209; -.
DR HGNC; HGNC:21898; TMEM209.
DR HPA; ENSG00000146842; Low tissue specificity.
DR neXtProt; NX_Q96SK2; -.
DR OpenTargets; ENSG00000146842; -.
DR PharmGKB; PA162406425; -.
DR VEuPathDB; HostDB:ENSG00000146842; -.
DR eggNOG; KOG4670; Eukaryota.
DR GeneTree; ENSGT00390000013963; -.
DR HOGENOM; CLU_028470_0_0_1; -.
DR InParanoid; Q96SK2; -.
DR OMA; WDSSLPT; -.
DR PhylomeDB; Q96SK2; -.
DR TreeFam; TF320043; -.
DR PathwayCommons; Q96SK2; -.
DR SignaLink; Q96SK2; -.
DR BioGRID-ORCS; 84928; 28 hits in 1085 CRISPR screens.
DR ChiTaRS; TMEM209; human.
DR GenomeRNAi; 84928; -.
DR Pharos; Q96SK2; Tdark.
DR PRO; PR:Q96SK2; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q96SK2; protein.
DR Bgee; ENSG00000146842; Expressed in adrenal tissue and 186 other tissues.
DR ExpressionAtlas; Q96SK2; baseline and differential.
DR Genevisible; Q96SK2; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR019176; Cytochrome_B561-rel.
DR PANTHER; PTHR21780; PTHR21780; 1.
DR Pfam; PF09786; CytochromB561_N; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..561
FT /note="Transmembrane protein 209"
FT /id="PRO_0000331632"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 119..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 11
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 98
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18691976,
FT ECO:0007744|PubMed:20068231"
FT MOD_RES 201
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 222
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 248
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18691976,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"
FT MOD_RES 278
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 274
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_033280"
FT VAR_SEQ 192..203
FT /note="LASFSPSPPSPY -> VMTLFSCLVTLF (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033281"
FT VAR_SEQ 204..561
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033282"
FT VAR_SEQ 375..416
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033283"
FT VARIANT 469
FT /note="P -> R (in dbSNP:rs17857472)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_042918"
FT VARIANT 505
FT /note="H -> R (in dbSNP:rs17854938)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_042919"
FT CONFLICT 379
FT /note="S -> G (in Ref. 1; BAC11168)"
FT /evidence="ECO:0000305"
FT CONFLICT 395
FT /note="N -> D (in Ref. 1; BAB55314)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 561 AA; 62922 MW; 0075314FEBC3DBA7 CRC64;
MMQGEAHPSA SLIDRTIKMR KETEARKVVL AWGLLNVSMA GMIYTEMTGK LISSYYNVTY
WPLWYIELAL ASLFSLNALF DFWRYFKYTV APTSLVVSPG QQTLLGLKTA VVQTTPPHDL
AATQIPPAPP SPSIQGQSVL SYSPSRSPST SPKFTTSCMT GYSPQLQGLS SGGSGSYSPG
VTYSPVSGYN KLASFSPSPP SPYPTTVGPV ESSGLRSRYR SSPTVYNSPT DKEDYMTDLR
TLDTFLRSEE EKQHRVKLGS PDSTSPSSSP TFWNYSRSMG DYAQTLKKFQ YQLACRSQAP
CANKDEADLS SKQAAEEVWA RVAMNRQLLD HMDSWTAKFR NWINETILVP LVQEIESVST
QMRRMGCPEL QIGEASITSL KQAALVKAPL IPTLNTIVQY LDLTPNQEYL FERIKELSQG
GCMSSFRWNR GGDFKGRKWD TDLPTDSAII MHVFCTYLDS RLPPHPKYPD GKTFTSQHFV
QTPNKPDVTN ENVFCIYQSA INPPHYELIY QRHVYNLPKG RNNMFHTLLM FLYIIKTKES
GMLGRVNLGL SGVNILWIFG E
