TM209_MOUSE
ID TM209_MOUSE Reviewed; 561 AA.
AC Q8BRG8; Q80WQ3; Q8BP02; Q8C202; Q8CDY5;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Transmembrane protein 209;
GN Name=Tmem209;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J;
RC TISSUE=Embryo, Head, Muellerian duct, and Submandibular gland;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BRG8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BRG8-2; Sequence=VSP_033284;
CC Name=3;
CC IsoId=Q8BRG8-3; Sequence=VSP_033285, VSP_033286;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC41016.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK029366; BAC26420.1; -; mRNA.
DR EMBL; AK044877; BAC32126.1; -; mRNA.
DR EMBL; AK078544; BAC37329.1; -; mRNA.
DR EMBL; AK089962; BAC41016.1; ALT_FRAME; mRNA.
DR EMBL; BC057109; AAH57109.1; -; mRNA.
DR EMBL; BC052187; AAH52187.1; -; mRNA.
DR CCDS; CCDS19972.1; -. [Q8BRG8-1]
DR CCDS; CCDS80511.1; -. [Q8BRG8-2]
DR RefSeq; NP_001298022.1; NM_001311093.1. [Q8BRG8-2]
DR RefSeq; NP_848740.3; NM_178625.4. [Q8BRG8-1]
DR RefSeq; XP_006505233.2; XM_006505170.3. [Q8BRG8-2]
DR AlphaFoldDB; Q8BRG8; -.
DR BioGRID; 215490; 1.
DR IntAct; Q8BRG8; 2.
DR STRING; 10090.ENSMUSP00000110813; -.
DR GlyGen; Q8BRG8; 2 sites.
DR iPTMnet; Q8BRG8; -.
DR PhosphoSitePlus; Q8BRG8; -.
DR EPD; Q8BRG8; -.
DR MaxQB; Q8BRG8; -.
DR PaxDb; Q8BRG8; -.
DR PeptideAtlas; Q8BRG8; -.
DR PRIDE; Q8BRG8; -.
DR ProteomicsDB; 258916; -. [Q8BRG8-1]
DR ProteomicsDB; 258917; -. [Q8BRG8-2]
DR ProteomicsDB; 258918; -. [Q8BRG8-3]
DR Antibodypedia; 32026; 59 antibodies from 19 providers.
DR DNASU; 72649; -.
DR Ensembl; ENSMUST00000064330; ENSMUSP00000067667; ENSMUSG00000029782. [Q8BRG8-3]
DR Ensembl; ENSMUST00000115157; ENSMUSP00000110810; ENSMUSG00000029782. [Q8BRG8-2]
DR Ensembl; ENSMUST00000115160; ENSMUSP00000110813; ENSMUSG00000029782. [Q8BRG8-1]
DR Ensembl; ENSMUST00000138823; ENSMUSP00000138292; ENSMUSG00000029782. [Q8BRG8-1]
DR GeneID; 72649; -.
DR KEGG; mmu:72649; -.
DR UCSC; uc009bfi.1; mouse. [Q8BRG8-3]
DR UCSC; uc009bfj.1; mouse. [Q8BRG8-1]
DR CTD; 84928; -.
DR MGI; MGI:1919899; Tmem209.
DR VEuPathDB; HostDB:ENSMUSG00000029782; -.
DR eggNOG; KOG4670; Eukaryota.
DR GeneTree; ENSGT00390000013963; -.
DR InParanoid; Q8BRG8; -.
DR OMA; WDSSLPT; -.
DR OrthoDB; 1481817at2759; -.
DR PhylomeDB; Q8BRG8; -.
DR TreeFam; TF320043; -.
DR BioGRID-ORCS; 72649; 9 hits in 73 CRISPR screens.
DR ChiTaRS; Tmem209; mouse.
DR PRO; PR:Q8BRG8; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8BRG8; protein.
DR Bgee; ENSMUSG00000029782; Expressed in spermatocyte and 248 other tissues.
DR ExpressionAtlas; Q8BRG8; baseline and differential.
DR Genevisible; Q8BRG8; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR019176; Cytochrome_B561-rel.
DR PANTHER; PTHR21780; PTHR21780; 1.
DR Pfam; PF09786; CytochromB561_N; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..561
FT /note="Transmembrane protein 209"
FT /id="PRO_0000331633"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 120..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 11
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96SK2"
FT MOD_RES 98
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96SK2"
FT MOD_RES 201
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96SK2"
FT MOD_RES 248
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96SK2"
FT MOD_RES 278
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96SK2"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 274
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033284"
FT VAR_SEQ 342..448
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033285"
FT VAR_SEQ 545..561
FT /note="RVNLGLSGVNILWIFGE -> N (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033286"
FT CONFLICT 39
FT /note="M -> I (in Ref. 1; BAC37329)"
FT /evidence="ECO:0000305"
FT CONFLICT 68
FT /note="L -> V (in Ref. 1; BAC37329)"
FT /evidence="ECO:0000305"
FT CONFLICT 407
FT /note="Q -> R (in Ref. 1; BAC37329)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 561 AA; 62982 MW; 0BE88792DD6BAE05 CRC64;
MMQGDVSPNP SLIDRTIKMR KETETRKVVL AWGLLNVSMA GMIYTEMTGK LISTYYNVTY
WPLWYIELAL ASLFSLNALF DFWRYFKYTV APTSLVVSPG QQALLGLKQA VVQTTPPRDL
AATQISPSPP SPSIQGQSVL SYSPSRSPST SPKFATSCMT GYSPQLQGLS SGGLGSYSPG
VTYSPVSGYN KLASFSLSPS SPYPTTVGPV ESSGLRARYR SPPTVYNSPT DKEDYMTDLR
TLDTFLRSEE EKQHRVKLGS PDSTSPSTSP TFWNYSRSVG DYAQTLKKFQ YQLACRSQAP
CANKDEADLI SKQAAEEVWA RVTMNRQLLD HMDSWTAKFR NWISETILVP LVQEIESVST
QMRRMGCPEL QIGEASVTSL KQAALVRAPL IPTLNAIVQY LDLTPNQEYL FERIKELSQG
GCMSSFRWNR GGDFKGRKWD TDLPTDSAII MHVFCTYLDS RLPPHPKYPD GKTFTSQHFV
QTPNKPDVTN ENVFCIYQSA VNPPHYELIY QRHVYNLPKG RNNMFHTLLM FLYIIKTKES
GMLGRVNLGL SGVNILWIFG E
