TM20B_DANRE
ID TM20B_DANRE Reviewed; 146 AA.
AC Q6DH66;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Mitochondrial import receptor subunit TOM20 homolog B;
DE AltName: Full=Mitochondrial 20 kDa outer membrane protein B;
DE AltName: Full=Outer mitochondrial membrane receptor Tom20-B;
GN Name=tomm20b; ORFNames=zgc:92628;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18307296; DOI=10.1021/pr700667w;
RA Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J.,
RA Slijper M., Heck A.J.R.;
RT "Online automated in vivo zebrafish phosphoproteomics: from large-scale
RT analysis down to a single embryo.";
RL J. Proteome Res. 7:1555-1564(2008).
CC -!- FUNCTION: Central component of the receptor complex responsible for the
CC recognition and translocation of cytosolically synthesized
CC mitochondrial preproteins. Together with tom22 functions as the transit
CC peptide receptor at the surface of the mitochondrion outer membrane and
CC facilitates the movement of preproteins into the tom40 translocation
CC pore (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC mitochondrial membrane (TOM complex). Interacts with tom22 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000250|UniProtKB:Q15388}; Single-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the Tom20 family. {ECO:0000305}.
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DR EMBL; BC076116; AAH76116.1; -; mRNA.
DR RefSeq; NP_001002698.1; NM_001002698.1.
DR AlphaFoldDB; Q6DH66; -.
DR SMR; Q6DH66; -.
DR BioGRID; 92128; 1.
DR iPTMnet; Q6DH66; -.
DR PRIDE; Q6DH66; -.
DR Ensembl; ENSDART00000158939; ENSDARP00000130577; ENSDARG00000103566.
DR GeneID; 436971; -.
DR KEGG; dre:436971; -.
DR CTD; 436971; -.
DR ZFIN; ZDB-GENE-040718-451; tomm20b.
DR GeneTree; ENSGT00390000011698; -.
DR HOGENOM; CLU_100000_1_1_1; -.
DR InParanoid; Q6DH66; -.
DR OMA; CFYSALK; -.
DR OrthoDB; 1316067at2759; -.
DR PhylomeDB; Q6DH66; -.
DR TreeFam; TF106200; -.
DR Reactome; R-DRE-5205685; PINK1-PRKN Mediated Mitophagy.
DR Reactome; R-DRE-5689880; Ub-specific processing proteases.
DR PRO; PR:Q6DH66; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 11.
DR Bgee; ENSDARG00000103566; Expressed in muscle tissue and 27 other tissues.
DR ExpressionAtlas; Q6DH66; baseline.
DR GO; GO:0031307; C:integral component of mitochondrial outer membrane; IBA:GO_Central.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IBA:GO_Central.
DR GO; GO:0030943; F:mitochondrion targeting sequence binding; IBA:GO_Central.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0016031; P:tRNA import into mitochondrion; IBA:GO_Central.
DR Gene3D; 1.20.960.10; -; 1.
DR InterPro; IPR002056; MAS20.
DR InterPro; IPR022422; MAS20_rcpt_metazoan.
DR InterPro; IPR023392; Tom20_dom_sf.
DR PANTHER; PTHR12430; PTHR12430; 1.
DR Pfam; PF02064; MAS20; 1.
DR PIRSF; PIRSF037707; MAS20_rcpt; 1.
DR PRINTS; PR01989; EUOM20RECPTR.
DR PRINTS; PR00351; OM20RECEPTOR.
DR SUPFAM; SSF47157; SSF47157; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein;
KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..146
FT /note="Mitochondrial import receptor subunit TOM20 homolog
FT B"
FT /id="PRO_0000317744"
FT TOPO_DOM 1..5
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 26..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 37..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 141
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18307296"
SQ SEQUENCE 146 AA; 16292 MW; A42C14939D018CD0 CRC64;
MMGGSSSRIA AGLGAALFVG YCIYFDRKRR SDPNYKNKLR ERRKKQKAAQ EKAGLSRLPD
LKDAEAVQKF FLEEIQLGEE LLAQGDYEKG VDHLTNAIAV CGQPQQLLQV LQQTLPPPVF
QMLLTKLPTI SQRIVSAQSI SDDDIE
