TM210_HUMAN
ID TM210_HUMAN Reviewed; 147 AA.
AC A6NLX4;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Transmembrane protein 210;
DE Flags: Precursor;
GN Name=TMEM210;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL929554; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS65197.1; -.
DR RefSeq; NP_001269406.1; NM_001282477.1.
DR AlphaFoldDB; A6NLX4; -.
DR PhosphoSitePlus; A6NLX4; -.
DR BioMuta; TMEM210; -.
DR MassIVE; A6NLX4; -.
DR PaxDb; A6NLX4; -.
DR PeptideAtlas; A6NLX4; -.
DR PRIDE; A6NLX4; -.
DR Antibodypedia; 56627; 4 antibodies from 4 providers.
DR DNASU; 100505993; -.
DR Ensembl; ENST00000413619.3; ENSP00000456333.2; ENSG00000185863.8.
DR GeneID; 100505993; -.
DR KEGG; hsa:100505993; -.
DR MANE-Select; ENST00000413619.3; ENSP00000456333.2; NM_001282477.2; NP_001269406.1.
DR UCSC; uc033dlm.2; human.
DR CTD; 100505993; -.
DR GeneCards; TMEM210; -.
DR HGNC; HGNC:34059; TMEM210.
DR HPA; ENSG00000185863; Tissue enriched (testis).
DR neXtProt; NX_A6NLX4; -.
DR OpenTargets; ENSG00000185863; -.
DR VEuPathDB; HostDB:ENSG00000185863; -.
DR eggNOG; ENOG502THU2; Eukaryota.
DR GeneTree; ENSGT00390000008939; -.
DR HOGENOM; CLU_148113_0_0_1; -.
DR InParanoid; A6NLX4; -.
DR OMA; CFCALII; -.
DR OrthoDB; 1493786at2759; -.
DR PhylomeDB; A6NLX4; -.
DR TreeFam; TF338189; -.
DR PathwayCommons; A6NLX4; -.
DR SignaLink; A6NLX4; -.
DR BioGRID-ORCS; 100505993; 7 hits in 930 CRISPR screens.
DR GenomeRNAi; 100505993; -.
DR Pharos; A6NLX4; Tdark.
DR PRO; PR:A6NLX4; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; A6NLX4; protein.
DR Bgee; ENSG00000185863; Expressed in right testis and 59 other tissues.
DR ExpressionAtlas; A6NLX4; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028123; TMEM210.
DR PANTHER; PTHR39234; PTHR39234; 1.
DR Pfam; PF15195; TMEM210; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..147
FT /note="Transmembrane protein 210"
FT /id="PRO_0000329080"
FT TOPO_DOM 32..47
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 128..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 147 AA; 15516 MW; 636450CC13451BF2 CRC64;
MAPGPWPVSC LRGGPLGLTY LSLLLIPAAA GTYCECSLGL SREALIALLV VLAGISASCF
CALVIVAIGV LRAKGETCPR QVDNRLVENF GVQEDLMDLH PVYVESQLMD ADLEVSLVPP
LEDQSLVAIP MEASSEEPPP PPPLPPE
