TM212_HUMAN
ID TM212_HUMAN Reviewed; 194 AA.
AC A6NML5;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Transmembrane protein 212;
GN Name=TMEM212;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK026825; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC055714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS46958.1; -.
DR RefSeq; NP_001157908.1; NM_001164436.1.
DR RefSeq; XP_011511119.1; XM_011512817.1.
DR AlphaFoldDB; A6NML5; -.
DR BioGRID; 133020; 1.
DR STRING; 9606.ENSP00000334072; -.
DR TCDB; 1.A.37.7.1; the cd20 ca(2+) channel (cd20) family.
DR BioMuta; TMEM212; -.
DR PaxDb; A6NML5; -.
DR PeptideAtlas; A6NML5; -.
DR PRIDE; A6NML5; -.
DR ProteomicsDB; 1546; -.
DR Antibodypedia; 64009; 8 antibodies from 5 providers.
DR DNASU; 389177; -.
DR Ensembl; ENST00000334567.9; ENSP00000334072.5; ENSG00000186329.9.
DR Ensembl; ENST00000619900.4; ENSP00000484106.1; ENSG00000186329.9.
DR GeneID; 389177; -.
DR KEGG; hsa:389177; -.
DR MANE-Select; ENST00000334567.9; ENSP00000334072.5; NM_001164436.2; NP_001157908.1.
DR UCSC; uc003fhw.2; human.
DR CTD; 389177; -.
DR DisGeNET; 389177; -.
DR GeneCards; TMEM212; -.
DR HGNC; HGNC:34295; TMEM212.
DR HPA; ENSG00000186329; Tissue enhanced (brain, fallopian tube).
DR neXtProt; NX_A6NML5; -.
DR OpenTargets; ENSG00000186329; -.
DR PharmGKB; PA162406475; -.
DR VEuPathDB; HostDB:ENSG00000186329; -.
DR eggNOG; ENOG502RXQ2; Eukaryota.
DR GeneTree; ENSGT00390000016029; -.
DR InParanoid; A6NML5; -.
DR OMA; PYCYYSF; -.
DR OrthoDB; 1485051at2759; -.
DR PhylomeDB; A6NML5; -.
DR TreeFam; TF337661; -.
DR PathwayCommons; A6NML5; -.
DR SignaLink; A6NML5; -.
DR BioGRID-ORCS; 389177; 8 hits in 1067 CRISPR screens.
DR ChiTaRS; TMEM212; human.
DR GenomeRNAi; 389177; -.
DR Pharos; A6NML5; Tdark.
DR PRO; PR:A6NML5; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; A6NML5; protein.
DR Bgee; ENSG00000186329; Expressed in buccal mucosa cell and 113 other tissues.
DR ExpressionAtlas; A6NML5; baseline and differential.
DR Genevisible; A6NML5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR030417; MS4A.
DR PANTHER; PTHR23320; PTHR23320; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..194
FT /note="Transmembrane protein 212"
FT /id="PRO_0000341207"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 194 AA; 21425 MW; 940FF9F9630714AA CRC64;
MKGLYQAAGR ILVTLGILSV CSGVIAFFPV FSYKPWFTGW SVRIACPIWN GALAITTGVL
LLLAYREWTQ RYLGEATFTF VILSIMGCPL HFAIALESAL LGPYCFYSFS GIAGTNYLGY
AVTFPYPYAK FPLACVDPPH YEEYHLTLQA LDLCLSFTLL CTSLTVFIKL SARLIQNGHI
NMQLPAGNPN PFSP
