TM212_MOUSE
ID TM212_MOUSE Reviewed; 187 AA.
AC Q8C6V3; Q0VE21;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Transmembrane protein 212;
GN Name=Tmem212;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC35275.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK053134; BAC35275.1; ALT_INIT; mRNA.
DR EMBL; BC119391; AAI19392.1; -; mRNA.
DR EMBL; BC119393; AAI19394.1; -; mRNA.
DR CCDS; CCDS50876.1; -.
DR RefSeq; NP_001157909.1; NM_001164437.1.
DR AlphaFoldDB; Q8C6V3; -.
DR STRING; 10090.ENSMUSP00000049832; -.
DR PaxDb; Q8C6V3; -.
DR PRIDE; Q8C6V3; -.
DR Antibodypedia; 64009; 8 antibodies from 5 providers.
DR Ensembl; ENSMUST00000058077; ENSMUSP00000049832; ENSMUSG00000043164.
DR GeneID; 208613; -.
DR KEGG; mmu:208613; -.
DR UCSC; uc008ots.2; mouse.
DR CTD; 389177; -.
DR MGI; MGI:2685410; Tmem212.
DR VEuPathDB; HostDB:ENSMUSG00000043164; -.
DR eggNOG; ENOG502RXQ2; Eukaryota.
DR GeneTree; ENSGT00390000016029; -.
DR HOGENOM; CLU_097593_0_0_1; -.
DR InParanoid; Q8C6V3; -.
DR OMA; PYCYYSF; -.
DR OrthoDB; 1485051at2759; -.
DR PhylomeDB; Q8C6V3; -.
DR TreeFam; TF337661; -.
DR BioGRID-ORCS; 208613; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q8C6V3; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8C6V3; protein.
DR Bgee; ENSMUSG00000043164; Expressed in right lung lobe and 42 other tissues.
DR Genevisible; Q8C6V3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR030417; MS4A.
DR PANTHER; PTHR23320; PTHR23320; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..187
FT /note="Transmembrane protein 212"
FT /id="PRO_0000341208"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 187 AA; 20747 MW; 78B036793BECCF2C CRC64;
MKGLYQAAGR TLVTLGGLSI FSGAIAFFPV FSCKLWYTGW SVWIACPIWN GALAVTAGSL
VLLAHREWTQ RHLWEAVFTF VILSILGCPL HFTVALQSAL LGPYCFYSFS GVAGTNYLGY
VVTFPFPYTK FPSVCVDPLH YEEYHLTLQV LDLCLSLILF CVSLAVFIKL SARLMQTGYI
NGPENPQ
