ID   TM214_BOVIN             Reviewed;         687 AA.
AC   A4FV45;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Transmembrane protein 214;
GN   Name=TMEM214;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Critical mediator, in cooperation with CASP4, of endoplasmic
CC       reticulum-stress induced apoptosis. Required or the activation of CASP4
CC       following endoplasmic reticulum stress (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Constitutively interacts with CASP4; required for the
CC       localization of procaspase 4 to the ER. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM214 family. {ECO:0000305}.
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DR   EMBL; BC123724; AAI23725.1; -; mRNA.
DR   RefSeq; NP_001076901.1; NM_001083432.1.
DR   AlphaFoldDB; A4FV45; -.
DR   STRING; 9913.ENSBTAP00000023162; -.
DR   PaxDb; A4FV45; -.
DR   PeptideAtlas; A4FV45; -.
DR   PRIDE; A4FV45; -.
DR   Ensembl; ENSBTAT00000023162; ENSBTAP00000023162; ENSBTAG00000017423.
DR   GeneID; 514683; -.
DR   KEGG; bta:514683; -.
DR   CTD; 54867; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017423; -.
DR   VGNC; VGNC:36036; TMEM214.
DR   eggNOG; KOG4467; Eukaryota.
DR   GeneTree; ENSGT00390000002693; -.
DR   HOGENOM; CLU_025330_1_0_1; -.
DR   InParanoid; A4FV45; -.
DR   OMA; IGQNWPS; -.
DR   OrthoDB; 1409017at2759; -.
DR   TreeFam; TF329489; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000017423; Expressed in saliva-secreting gland and 106 other tissues.
DR   GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR019308; TMEM214.
DR   PANTHER; PTHR13448; PTHR13448; 1.
DR   Pfam; PF10151; TMEM214; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Apoptosis; Endoplasmic reticulum; Glycoprotein; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NUQ4"
FT   CHAIN           2..687
FT                   /note="Transmembrane protein 214"
FT                   /id="PRO_0000321896"
FT   TRANSMEM        475..495
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        614..634
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          68..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NUQ4"
FT   CARBOHYD        267
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        305
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   687 AA;  77016 MW;  5B2316B8811E7C5A CRC64;
     MAAKTAGGGR WEVVKKGRRP GAGGSGKGGG GDRRALGEAN GVWKYDLTPP IQTTSTLYER
     GFEKIMKRQN KEQVPPPAVE PKKPGNKKQA KKVATLTNQN QKQGRFRSLE EALKALDLAD
     LQKELDKSQS VFSGNPSVWL KDLASYLNYK LQVPPSEPTL SQHPHDYPYS LVSRELRGII
     RGLLAKAAGS LELFFDHCLF TMLQELDKTP GESLHGYRIC IQAILQDKPK IVTTNLGKFL
     ELLRSHQSRP AKCLTIMWAL GQAGFTNLTE GLRVWLGIML PVLGIKSLSP FAIAYLDRLL
     LMHPNLTKGF GMIGPKDLFP LLDFAYMPNN SLTPSLQEQL CQLYPRLKVL AFGAKPESTL
     HTYFPSFLSR ATPGCPLEMK KELLRSLTEC LMVDPLSTSV WRQLYPKHLS QSSLLLEHLL
     RSWERIPKKT QKSLQETIQS FKLTNQDLLR KGGGSNQDVV TCDSACKSLL QQARGFQLPW
     TRLLLLVLVF AIGFLCHDFR SHSSFQASLS GQLLQSSGVL PAGQQACTKI YSYSLQGYSW
     LEKTLPAWGS HLLTVVRPGL QLAWAHTNAT VGFLSAHCAS HLAWFGDSLA NLFQRLQTQL
     PDTLNQLLRS LRELLLFLYH SILLPTWHML LEALAQIQEH CHEACRGEVT WDCMKTQLSE
     AAHWTWLRLQ DTTVAFLDWA LAMISQQ