TM215_HUMAN
ID TM215_HUMAN Reviewed; 235 AA.
AC Q68D42; Q6ZUU2;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Transmembrane protein 215;
GN Name=TMEM215;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Retina;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK125320; BAC86126.1; -; mRNA.
DR EMBL; BX647550; CAH56136.1; -; mRNA.
DR EMBL; CR749589; CAH18388.1; -; mRNA.
DR EMBL; CH471071; EAW58539.1; -; Genomic_DNA.
DR CCDS; CCDS6530.1; -.
DR RefSeq; NP_997723.2; NM_212558.2.
DR AlphaFoldDB; Q68D42; -.
DR STRING; 9606.ENSP00000345468; -.
DR iPTMnet; Q68D42; -.
DR PhosphoSitePlus; Q68D42; -.
DR BioMuta; TMEM215; -.
DR DMDM; 74748275; -.
DR MassIVE; Q68D42; -.
DR PaxDb; Q68D42; -.
DR PeptideAtlas; Q68D42; -.
DR PRIDE; Q68D42; -.
DR ProteomicsDB; 66049; -.
DR Antibodypedia; 63219; 22 antibodies from 9 providers.
DR DNASU; 401498; -.
DR Ensembl; ENST00000342743.6; ENSP00000345468.5; ENSG00000188133.6.
DR GeneID; 401498; -.
DR KEGG; hsa:401498; -.
DR MANE-Select; ENST00000342743.6; ENSP00000345468.5; NM_212558.3; NP_997723.2.
DR UCSC; uc003zri.5; human.
DR CTD; 401498; -.
DR DisGeNET; 401498; -.
DR GeneCards; TMEM215; -.
DR HGNC; HGNC:33816; TMEM215.
DR HPA; ENSG00000188133; Tissue enhanced (brain, retina, testis).
DR neXtProt; NX_Q68D42; -.
DR OpenTargets; ENSG00000188133; -.
DR PharmGKB; PA162406544; -.
DR VEuPathDB; HostDB:ENSG00000188133; -.
DR eggNOG; ENOG502QZ55; Eukaryota.
DR GeneTree; ENSGT00390000006684; -.
DR HOGENOM; CLU_1165487_0_0_1; -.
DR InParanoid; Q68D42; -.
DR OMA; DRSDCPE; -.
DR OrthoDB; 1440273at2759; -.
DR PhylomeDB; Q68D42; -.
DR TreeFam; TF335695; -.
DR PathwayCommons; Q68D42; -.
DR BioGRID-ORCS; 401498; 6 hits in 1064 CRISPR screens.
DR GenomeRNAi; 401498; -.
DR Pharos; Q68D42; Tdark.
DR PRO; PR:Q68D42; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q68D42; protein.
DR Bgee; ENSG00000188133; Expressed in tibial nerve and 41 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031486; TMEM215.
DR PANTHER; PTHR31922; PTHR31922; 1.
DR Pfam; PF15746; TMEM215; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..235
FT /note="Transmembrane protein 215"
FT /id="PRO_0000319324"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 99..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 69
FT /note="W -> R (in Ref. 1; BAC86126)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 235 AA; 25806 MW; B8381021EBBBB0F6 CRC64;
MRPDDINPRT GLVVALVSVF LVFGFMFTVS GMKGETLGNI PLLAIGPAIC LPGIAAIALA
RKTEGCTKWP ENELLWVRKL PCFRKPKDKE VVELLRTPSD LESGKGSSDE LAKKAGLRGK
PPPQSQGEVS VASSINSPTP TEEGECQSLV QNGHQEETSR YLDGYCPSGS SLTYSALDVK
CSARDRSECP EPEDSIFFVP QDSIIVCSYK QNSPYDRYCC YINQIQGRWD HETIV
