TM215_MOUSE
ID TM215_MOUSE Reviewed; 235 AA.
AC A7E1Z1; Q8C8R5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Transmembrane protein 215;
GN Name=Tmem215;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK044627; BAC32008.1; -; mRNA.
DR EMBL; AL844182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC148227; AAI48228.1; -; mRNA.
DR EMBL; BC148284; AAI48285.1; -; mRNA.
DR CCDS; CCDS18046.1; -.
DR RefSeq; NP_001159481.1; NM_001166009.1.
DR RefSeq; NP_796149.2; NM_177175.4.
DR AlphaFoldDB; A7E1Z1; -.
DR BioGRID; 236071; 1.
DR STRING; 10090.ENSMUSP00000052129; -.
DR iPTMnet; A7E1Z1; -.
DR PhosphoSitePlus; A7E1Z1; -.
DR PaxDb; A7E1Z1; -.
DR PRIDE; A7E1Z1; -.
DR ProteomicsDB; 258923; -.
DR Antibodypedia; 63219; 22 antibodies from 9 providers.
DR DNASU; 320500; -.
DR Ensembl; ENSMUST00000049655; ENSMUSP00000052129; ENSMUSG00000046593.
DR Ensembl; ENSMUST00000179526; ENSMUSP00000136595; ENSMUSG00000046593.
DR GeneID; 320500; -.
DR KEGG; mmu:320500; -.
DR UCSC; uc008shm.1; mouse.
DR CTD; 401498; -.
DR MGI; MGI:2444167; Tmem215.
DR VEuPathDB; HostDB:ENSMUSG00000046593; -.
DR eggNOG; ENOG502QZ55; Eukaryota.
DR GeneTree; ENSGT00390000006684; -.
DR HOGENOM; CLU_1165487_0_0_1; -.
DR InParanoid; A7E1Z1; -.
DR OMA; DRSDCPE; -.
DR OrthoDB; 1440273at2759; -.
DR PhylomeDB; A7E1Z1; -.
DR TreeFam; TF335695; -.
DR BioGRID-ORCS; 320500; 0 hits in 74 CRISPR screens.
DR PRO; PR:A7E1Z1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A7E1Z1; protein.
DR Bgee; ENSMUSG00000046593; Expressed in islet of Langerhans and 48 other tissues.
DR ExpressionAtlas; A7E1Z1; baseline and differential.
DR Genevisible; A7E1Z1; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031486; TMEM215.
DR PANTHER; PTHR31922; PTHR31922; 1.
DR Pfam; PF15746; TMEM215; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..235
FT /note="Transmembrane protein 215"
FT /id="PRO_0000319325"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 99..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 79
FT /note="K -> R (in Ref. 1; BAC32008)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 235 AA; 25812 MW; 57D89C167B4339E5 CRC64;
MRPDDINPRT GLVVALVSVF LVFGFMFTVS GMKGETLGNI PLLAIGPAIC LPGIAAIALA
RKTEGCTKWP ENELLWVRKL PCFRKPKDKE VVELLRTPSD LESGKGSSDE LAKKAGLRGK
QLPQGPGEVP MASSVTTPTP TEEGECQSLV QSGRQEETSR YLDGYCPSAS SLAYSALDAK
CSAWDRSDRP EPEDSIFFVP QDSIIVCSYK QNSPYDRYCC YINQSQGRWD HETIV
