ID   TM216_BOVIN             Reviewed;         141 AA.
AC   Q2TA01; G5E5R2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2012, sequence version 2.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Transmembrane protein 216;
GN   Name=TMEM216;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA   Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA   Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the tectonic-like complex which is required for
CC       tissue-specific ciliogenesis and may regulate ciliary membrane
CC       composition. {ECO:0000250}.
CC   -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC       Interacts with TMEM107. {ECO:0000250|UniProtKB:Q9P0N5}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250}. Note=Localizes at the transition zone, a region between
CC       the basal body and the ciliary axoneme. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q2TA01-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q2TA01-2; Sequence=VSP_042589;
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DR   EMBL; DAAA02063463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC111187; AAI11188.1; -; mRNA.
DR   RefSeq; NP_001160035.1; NM_001166563.2. [Q2TA01-2]
DR   RefSeq; XP_005226951.1; XM_005226894.3.
DR   RefSeq; XP_010819304.1; XM_010821002.2. [Q2TA01-1]
DR   RefSeq; XP_015316719.1; XM_015461233.1.
DR   AlphaFoldDB; Q2TA01; -.
DR   SMR; Q2TA01; -.
DR   STRING; 9913.ENSBTAP00000028677; -.
DR   PaxDb; Q2TA01; -.
DR   Ensembl; ENSBTAT00000028677; ENSBTAP00000028677; ENSBTAG00000021517. [Q2TA01-1]
DR   GeneID; 508031; -.
DR   KEGG; bta:508031; -.
DR   CTD; 51259; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021517; -.
DR   eggNOG; KOG4502; Eukaryota.
DR   GeneTree; ENSGT00940000153899; -.
DR   HOGENOM; CLU_135948_0_0_1; -.
DR   InParanoid; Q2TA01; -.
DR   OMA; QFPWGLK; -.
DR   OrthoDB; 1584392at2759; -.
DR   TreeFam; TF323824; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000021517; Expressed in oviduct epithelium and 104 other tissues.
DR   GO; GO:0035869; C:ciliary transition zone; IBA:GO_Central.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0036038; C:MKS complex; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:1905515; P:non-motile cilium assembly; IBA:GO_Central.
DR   InterPro; IPR019184; Uncharacterised_TM-17.
DR   PANTHER; PTHR13531; PTHR13531; 1.
DR   Pfam; PF09799; Transmemb_17; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell projection; Cilium biogenesis/degradation;
KW   Cytoplasm; Cytoskeleton; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..141
FT                   /note="Transmembrane protein 216"
FT                   /id="PRO_0000318954"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..54
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_042589"
SQ   SEQUENCE   141 AA;  16186 MW;  970FD4525EB8848D CRC64;
     MAPRGKRLSS TPLEILFFLN GWYYATYFLL ELFIFLYKGL LLPYPTANLV LDVVMLFLYL
     GVEVIRLFFG TKGNLCQRKM PLGISVALTF PSTMMASYYL LLQTYVLRLE AIMNSILLFF
     CGSELLLEVL TLTAFSSMDR M