ID   TM218_BOVIN             Reviewed;         115 AA.
AC   A5PJF4;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Transmembrane protein 218;
GN   Name=TMEM218;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in ciliary biogenesis or function.
CC       {ECO:0000250|UniProtKB:Q9CQ44}.
CC   -!- SUBUNIT: Interacts with TMEM67. {ECO:0000250|UniProtKB:A2RU14}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q9CQ44}. Note=Localizes at the transition zone,
CC       a region between the basal body and the ciliary axoneme.
CC       {ECO:0000250|UniProtKB:Q9CQ44}.
CC   -!- SIMILARITY: Belongs to the TMEM218 family. {ECO:0000305}.
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DR   EMBL; BC142090; AAI42091.1; -; mRNA.
DR   RefSeq; NP_001092629.1; NM_001099159.1.
DR   AlphaFoldDB; A5PJF4; -.
DR   SMR; A5PJF4; -.
DR   STRING; 9913.ENSBTAP00000030281; -.
DR   PaxDb; A5PJF4; -.
DR   PRIDE; A5PJF4; -.
DR   Ensembl; ENSBTAT00000030297; ENSBTAP00000030281; ENSBTAG00000022382.
DR   GeneID; 616789; -.
DR   KEGG; bta:616789; -.
DR   CTD; 219854; -.
DR   VEuPathDB; HostDB:ENSBTAG00000022382; -.
DR   VGNC; VGNC:36040; TMEM218.
DR   eggNOG; ENOG502S2I1; Eukaryota.
DR   GeneTree; ENSGT00390000016247; -.
DR   HOGENOM; CLU_169774_0_0_1; -.
DR   InParanoid; A5PJF4; -.
DR   OMA; PATEMKI; -.
DR   OrthoDB; 1590037at2759; -.
DR   TreeFam; TF328597; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000022382; Expressed in pigment epithelium of eye and 103 other tissues.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026771; Tmem218.
DR   PANTHER; PTHR31622; PTHR31622; 1.
PE   3: Inferred from homology;
KW   Cell projection; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..115
FT                   /note="Transmembrane protein 218"
FT                   /id="PRO_0000321835"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   115 AA;  12350 MW;  C7CC2935F748C2D0 CRC64;
     MAGTVLGVGA GVFVLALLWV SVLLLCALLF RASGAARFSV IFVFLGALIV TAILLLFPRA
     SDAPAPEAET KIVDAFFIGR YVLLAFLTAV FLGSLFLVLI HHILEPIYAK PLRSY