ID   TM218_DANRE             Reviewed;         115 AA.
AC   Q7SZ56;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Transmembrane protein 218;
GN   Name=tmem218; ORFNames=zgc:63675;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=35137054; DOI=10.1093/hmg/ddac027;
RA   Epting D., Decker E., Ott E., Eisenberger T., Bader I., Bachmann N.,
RA   Bergmann C.;
RT   "The ciliary transition zone protein TMEM218 synergistically interacts with
RT   the NPHP module and its reduced dosage leads to a wide range of syndromic
RT   ciliopathies.";
RL   Hum. Mol. Genet. 0:0-0(2022).
CC   -!- FUNCTION: May be involved in ciliary biogenesis or function.
CC       {ECO:0000250|UniProtKB:Q9CQ44}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q9CQ44}. Note=Localizes at the transition zone,
CC       a region between the basal body and the ciliary axoneme.
CC       {ECO:0000250|UniProtKB:Q9CQ44}.
CC   -!- DISRUPTION PHENOTYPE: Morpholino knockdown leads to the formation of
CC       pronephric cysts and hydrocephalus, features consistent with a
CC       ciliopathy. {ECO:0000269|PubMed:35137054}.
CC   -!- SIMILARITY: Belongs to the TMEM218 family. {ECO:0000305}.
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DR   EMBL; BC054131; AAH54131.1; -; mRNA.
DR   RefSeq; NP_956692.1; NM_200398.2.
DR   AlphaFoldDB; Q7SZ56; -.
DR   SMR; Q7SZ56; -.
DR   STRING; 7955.ENSDARP00000028280; -.
DR   PaxDb; Q7SZ56; -.
DR   Ensembl; ENSDART00000140988; ENSDARP00000122434; ENSDARG00000027129.
DR   Ensembl; ENSDART00000185080; ENSDARP00000145554; ENSDARG00000027129.
DR   GeneID; 393369; -.
DR   KEGG; dre:393369; -.
DR   CTD; 219854; -.
DR   ZFIN; ZDB-GENE-040426-1232; tmem218.
DR   eggNOG; ENOG502S2I1; Eukaryota.
DR   GeneTree; ENSGT00390000016247; -.
DR   HOGENOM; CLU_169774_0_0_1; -.
DR   InParanoid; Q7SZ56; -.
DR   OMA; PATEMKI; -.
DR   PhylomeDB; Q7SZ56; -.
DR   TreeFam; TF328597; -.
DR   PRO; PR:Q7SZ56; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 10.
DR   Bgee; ENSDARG00000027129; Expressed in testis and 20 other tissues.
DR   ExpressionAtlas; Q7SZ56; baseline.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026771; Tmem218.
DR   PANTHER; PTHR31622; PTHR31622; 1.
PE   3: Inferred from homology;
KW   Cell projection; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..115
FT                   /note="Transmembrane protein 218"
FT                   /id="PRO_0000359898"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   115 AA;  12563 MW;  B11BBD6464E6DE46 CRC64;
     MADVVLGVGT GVFIITLIWI LTLALTIILS RATGPTKLGI IPVVLLALII TLVLVFFPRA
     AEVPAPQRAA QIVDMFFIGR YVLLSLVSLV FLAALFMLLP LHFLEPIYAK PLRTH