BST22_CAEEL
ID BST22_CAEEL Reviewed; 499 AA.
AC Q23369;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Bestrophin homolog 22;
GN Name=best-22; ORFNames=ZC518.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Forms chloride channels. {ECO:0000250}.
CC -!- SUBUNIT: Forms oligomers. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the bestrophin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z68753; CAA92989.1; -; Genomic_DNA.
DR PIR; T27630; T27630.
DR RefSeq; NP_502353.1; NM_069952.6.
DR AlphaFoldDB; Q23369; -.
DR SMR; Q23369; -.
DR STRING; 6239.ZC518.1a; -.
DR PaxDb; Q23369; -.
DR EnsemblMetazoa; ZC518.1a.1; ZC518.1a.1; WBGene00013921.
DR GeneID; 191197; -.
DR UCSC; ZC518.1a; c. elegans.
DR CTD; 191197; -.
DR WormBase; ZC518.1a; CE06601; WBGene00013921; best-22.
DR eggNOG; KOG3547; Eukaryota.
DR InParanoid; Q23369; -.
DR PhylomeDB; Q23369; -.
DR Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR PRO; PR:Q23369; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00013921; Expressed in larva and 3 other tissues.
DR ExpressionAtlas; Q23369; baseline and differential.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR InterPro; IPR000615; Bestrophin.
DR InterPro; IPR021134; Bestrophin/UPF0187.
DR PANTHER; PTHR10736; PTHR10736; 1.
DR Pfam; PF01062; Bestrophin; 1.
PE 3: Inferred from homology;
KW Cell membrane; Chloride; Chloride channel; Ion channel; Ion transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..499
FT /note="Bestrophin homolog 22"
FT /id="PRO_0000143134"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 417..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 499 AA; 57229 MW; 4E87725437A5C9DF CRC64;
MTISYTLDVS QTNLQSFFSL LLRWRGSVWK AVFGQLAVWT AVFLLISCIY RYMLSPSQQD
VFEQLIRYFD NKLDANIPLT FLLGFFVSFV VARWGSILNG IGWIDDASLL FATYIRGADE
ETRVIRRNLV RYLVLSQALV LRDISMQVRK RFPTMDTLAA SGLMTHEEMD ILDHIKDPYS
RYWTSIQWSL NLVYECQKKG KVDSYYLMNK IVDEIGKFRH GLASLLKYDW VPVPLVYPQV
IFLAVRIYFM ICLIGRQFIV TGPNPSGIDL WLPITTMVQF LVYMGWMKVA EALLNPLGED
DDDLECNYII DKNLITGLSI VDTMWKHDDT GYSMVEEHMA KTPAQKKDEF WGIDKIAPLY
SMESAERSVH PLVGSASKIN LVKNKKEIVM TPHKNKLSEL DPSEQKTYLR RVNVSDHNAK
HAKQRGLERA NSPDKCLSKM RSRSNGKFRT SANGSQNGVD LWTRAGDIEM NVATSNPNQV
HPHSIAVFPP EEQQTTSRH
