ID   TM218_RAT               Reviewed;         115 AA.
AC   Q5U3Y9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Transmembrane protein 218;
GN   Name=Tmem218;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in ciliary biogenesis or function.
CC       {ECO:0000250|UniProtKB:Q9CQ44}.
CC   -!- SUBUNIT: Interacts with TMEM67. {ECO:0000250|UniProtKB:A2RU14}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q9CQ44}. Note=Localizes at the transition zone,
CC       a region between the basal body and the ciliary axoneme.
CC       {ECO:0000250|UniProtKB:Q9CQ44}.
CC   -!- SIMILARITY: Belongs to the TMEM218 family. {ECO:0000305}.
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DR   EMBL; BC085342; AAH85342.1; -; mRNA.
DR   RefSeq; NP_001008326.1; NM_001008325.1.
DR   RefSeq; XP_008764272.1; XM_008766050.2.
DR   AlphaFoldDB; Q5U3Y9; -.
DR   SMR; Q5U3Y9; -.
DR   STRING; 10116.ENSRNOP00000012060; -.
DR   PaxDb; Q5U3Y9; -.
DR   Ensembl; ENSRNOT00000012060; ENSRNOP00000012060; ENSRNOG00000008757.
DR   GeneID; 300516; -.
DR   KEGG; rno:300516; -.
DR   UCSC; RGD:1311364; rat.
DR   CTD; 219854; -.
DR   RGD; 1311364; Tmem218.
DR   eggNOG; ENOG502S2I1; Eukaryota.
DR   GeneTree; ENSGT00390000016247; -.
DR   HOGENOM; CLU_169774_0_0_1; -.
DR   InParanoid; Q5U3Y9; -.
DR   OMA; PATEMKI; -.
DR   OrthoDB; 1590037at2759; -.
DR   PhylomeDB; Q5U3Y9; -.
DR   TreeFam; TF328597; -.
DR   PRO; PR:Q5U3Y9; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000008757; Expressed in liver and 20 other tissues.
DR   Genevisible; Q5U3Y9; RN.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026771; Tmem218.
DR   PANTHER; PTHR31622; PTHR31622; 1.
PE   3: Inferred from homology;
KW   Cell projection; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..115
FT                   /note="Transmembrane protein 218"
FT                   /id="PRO_0000321838"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   115 AA;  12479 MW;  82778CCE93595CAD CRC64;
     MAGMVLGVGA GVFLLALLWV LVLLLCVLLC RASGIARFSI IFVFLGALII TTVLLLFPRA
     SEFPAPQGEM KIVDAFFIGR YVLLAFLSAV FLGGLFLLLT HHVLEPIYAK PLRSC