ID   TM218_XENTR             Reviewed;         115 AA.
AC   B0JYX6;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Transmembrane protein 218;
GN   Name=tmem218;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in ciliary biogenesis or function.
CC       {ECO:0000250|UniProtKB:Q9CQ44}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q9CQ44}. Note=Localizes at the transition zone,
CC       a region between the basal body and the ciliary axoneme.
CC       {ECO:0000250|UniProtKB:Q9CQ44}.
CC   -!- SIMILARITY: Belongs to the TMEM218 family. {ECO:0000305}.
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DR   EMBL; BC158955; AAI58956.1; -; mRNA.
DR   RefSeq; NP_001016711.1; NM_001016711.3.
DR   RefSeq; XP_012822072.1; XM_012966618.2.
DR   RefSeq; XP_012822074.1; XM_012966620.2.
DR   AlphaFoldDB; B0JYX6; -.
DR   SMR; B0JYX6; -.
DR   PaxDb; B0JYX6; -.
DR   Ensembl; ENSXETT00000017280; ENSXETP00000017280; ENSXETG00000027473.
DR   GeneID; 549465; -.
DR   KEGG; xtr:549465; -.
DR   CTD; 219854; -.
DR   Xenbase; XB-GENE-955389; tmem218.
DR   eggNOG; ENOG502S2I1; Eukaryota.
DR   HOGENOM; CLU_169774_0_0_1; -.
DR   InParanoid; B0JYX6; -.
DR   OMA; DMTNTVL; -.
DR   OrthoDB; 1590037at2759; -.
DR   PhylomeDB; B0JYX6; -.
DR   TreeFam; TF328597; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000027473; Expressed in egg cell and 12 other tissues.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026771; Tmem218.
DR   PANTHER; PTHR31622; PTHR31622; 1.
PE   3: Inferred from homology;
KW   Cell projection; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..115
FT                   /note="Transmembrane protein 218"
FT                   /id="PRO_0000359899"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   115 AA;  12846 MW;  7966BD0C98D8D6C1 CRC64;
     MATTILGVGP GVFIIAVIWM VTLMLTVLLC RASGKARFWT VVVFTLALIT TLILVFFPRA
     SQTPAPAKEM QIVDTFFIGR YFLISIMSVI FLGCLFFVFV YHILEPVYAK PIGIH