ID   TM219_BOVIN             Reviewed;         239 AA.
AC   Q1JQE1;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Insulin-like growth factor-binding protein 3 receptor;
DE            Short=IGFBP-3R;
DE   AltName: Full=Transmembrane protein 219;
DE   Flags: Precursor;
GN   Name=TMEM219;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus, and Hereford; TISSUE=Ileum, and Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cell death receptor specific for IGFBP3, may mediate caspase-
CC       8-dependent apoptosis upon ligand binding. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with IGFBP3. Interacts with CASP8 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane
CC       protein.
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DR   EMBL; BC116008; AAI16009.1; -; mRNA.
DR   EMBL; BC151424; AAI51425.1; -; mRNA.
DR   RefSeq; NP_001073700.2; NM_001080231.1.
DR   RefSeq; NP_001231223.1; NM_001244294.1.
DR   AlphaFoldDB; Q1JQE1; -.
DR   STRING; 9913.ENSBTAP00000029038; -.
DR   PaxDb; Q1JQE1; -.
DR   Ensembl; ENSBTAT00000029038; ENSBTAP00000029038; ENSBTAG00000021785.
DR   Ensembl; ENSBTAT00000074830; ENSBTAP00000074543; ENSBTAG00000021785.
DR   GeneID; 506622; -.
DR   KEGG; bta:506622; -.
DR   CTD; 124446; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021785; -.
DR   VGNC; VGNC:36041; TMEM219.
DR   eggNOG; ENOG502S30C; Eukaryota.
DR   GeneTree; ENSGT00940000153883; -.
DR   HOGENOM; CLU_101408_0_0_1; -.
DR   InParanoid; Q1JQE1; -.
DR   OMA; GTTFFLC; -.
DR   OrthoDB; 1408433at2759; -.
DR   TreeFam; TF338507; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000021785; Expressed in prostate gland and 104 other tissues.
DR   ExpressionAtlas; Q1JQE1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR039493; TMEM248/TMEM219.
DR   InterPro; IPR039587; TMEM248/TMEM219_dom.
DR   PANTHER; PTHR16002; PTHR16002; 1.
DR   Pfam; PF14940; TMEM219; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cell membrane; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..38
FT                   /evidence="ECO:0000255"
FT   CHAIN           39..239
FT                   /note="Insulin-like growth factor-binding protein 3
FT                   receptor"
FT                   /id="PRO_0000420111"
FT   TOPO_DOM        39..205
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        227..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        101
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        167
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   239 AA;  25877 MW;  349FAD6A0DA95625 CRC64;
     MGSCQAGHYL HFCLAHHPPL VCATLILLLL GLSGLGLGGF LLTHRTDLRS PDIPQDWVSF
     LRSFGQLTLC PVNGTVTGKG RGSHIVGLLT TLNFGDGPDR NKTQTFQAQV QGSRMGLKGS
     FARELVLVTA RVTTERTPGT CLYFSAIPEI LPSSQPPIPC SEEGAGNATL SPRMSEECVG
     VWSHEGLVLT KLLTSEELTL CGSRLLVLGF FLILFCGLCC LTAACFHPRR ESHWSRTRL