TM219_HUMAN
ID TM219_HUMAN Reviewed; 240 AA.
AC Q86XT9; D5FK14; Q8WVV8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Insulin-like growth factor-binding protein 3 receptor;
DE Short=IGFBP-3R;
DE AltName: Full=Transmembrane protein 219;
DE Flags: Precursor;
GN Name=TMEM219;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION
RP WITH IGFBP3 AND CASP8, AND TISSUE SPECIFICITY.
RX PubMed=20353938; DOI=10.1074/jbc.m110.122226;
RA Ingermann A.R., Yang Y.F., Han J., Mikami A., Garza A.E., Mohanraj L.,
RA Fan L., Idowu M., Ware J.L., Kim H.S., Lee D.Y., Oh Y.;
RT "Identification of a novel cell death receptor mediating IGFBP-3-induced
RT anti-tumor effects in breast and prostate cancer.";
RL J. Biol. Chem. 285:30233-30246(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Cell death receptor specific for IGFBP3, may mediate caspase-
CC 8-dependent apoptosis upon ligand binding.
CC {ECO:0000269|PubMed:20353938}.
CC -!- SUBUNIT: Interacts with IGFBP3. Interacts with CASP8.
CC {ECO:0000269|PubMed:20353938}.
CC -!- INTERACTION:
CC Q86XT9; P17936: IGFBP3; NbExp=8; IntAct=EBI-20264080, EBI-715709;
CC Q86XT9; Q14627: IL13RA2; NbExp=9; IntAct=EBI-20264080, EBI-4320063;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20353938};
CC Single-pass membrane protein {ECO:0000269|PubMed:20353938}.
CC -!- TISSUE SPECIFICITY: Widely expressed in normal tissues but suppressed
CC in prostate and breast tumor. {ECO:0000269|PubMed:20353938}.
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DR EMBL; FJ748884; ACQ72822.1; -; mRNA.
DR EMBL; CH471238; EAW79966.1; -; Genomic_DNA.
DR EMBL; BC017488; AAH17488.1; -; mRNA.
DR EMBL; BC050051; AAH50051.1; -; mRNA.
DR CCDS; CCDS42145.1; -.
DR RefSeq; NP_001077082.1; NM_001083613.1.
DR RefSeq; NP_919256.1; NM_194280.3.
DR RefSeq; XP_005255180.1; XM_005255123.1.
DR AlphaFoldDB; Q86XT9; -.
DR BioGRID; 125865; 23.
DR IntAct; Q86XT9; 16.
DR STRING; 9606.ENSP00000457492; -.
DR GlyGen; Q86XT9; 3 sites.
DR iPTMnet; Q86XT9; -.
DR PhosphoSitePlus; Q86XT9; -.
DR BioMuta; TMEM219; -.
DR EPD; Q86XT9; -.
DR jPOST; Q86XT9; -.
DR MassIVE; Q86XT9; -.
DR PaxDb; Q86XT9; -.
DR PeptideAtlas; Q86XT9; -.
DR PRIDE; Q86XT9; -.
DR ProteomicsDB; 70333; -.
DR Antibodypedia; 68649; 10 antibodies from 7 providers.
DR DNASU; 124446; -.
DR Ensembl; ENST00000279396.11; ENSP00000279396.6; ENSG00000149932.17.
DR Ensembl; ENST00000414689.6; ENSP00000388485.2; ENSG00000149932.17.
DR Ensembl; ENST00000561899.6; ENSP00000456960.1; ENSG00000149932.17.
DR Ensembl; ENST00000566848.5; ENSP00000457492.1; ENSG00000149932.17.
DR Ensembl; ENST00000570255.6; ENSP00000459813.2; ENSG00000149932.17.
DR GeneID; 124446; -.
DR KEGG; hsa:124446; -.
DR MANE-Select; ENST00000279396.11; ENSP00000279396.6; NM_001083613.2; NP_001077082.1.
DR UCSC; uc002duw.3; human.
DR CTD; 124446; -.
DR DisGeNET; 124446; -.
DR GeneCards; TMEM219; -.
DR HGNC; HGNC:25201; TMEM219.
DR HPA; ENSG00000149932; Low tissue specificity.
DR neXtProt; NX_Q86XT9; -.
DR OpenTargets; ENSG00000149932; -.
DR PharmGKB; PA162406570; -.
DR VEuPathDB; HostDB:ENSG00000149932; -.
DR eggNOG; ENOG502S30C; Eukaryota.
DR GeneTree; ENSGT00940000153883; -.
DR HOGENOM; CLU_101408_0_0_1; -.
DR InParanoid; Q86XT9; -.
DR OMA; GTTFFLC; -.
DR OrthoDB; 1408433at2759; -.
DR PhylomeDB; Q86XT9; -.
DR TreeFam; TF338507; -.
DR PathwayCommons; Q86XT9; -.
DR Reactome; R-HSA-6803211; TP53 Regulates Transcription of Death Receptors and Ligands.
DR SignaLink; Q86XT9; -.
DR BioGRID-ORCS; 124446; 16 hits in 1084 CRISPR screens.
DR ChiTaRS; TMEM219; human.
DR GenomeRNAi; 124446; -.
DR Pharos; Q86XT9; Tdark.
DR PRO; PR:Q86XT9; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q86XT9; protein.
DR Bgee; ENSG00000149932; Expressed in right testis and 176 other tissues.
DR ExpressionAtlas; Q86XT9; baseline and differential.
DR Genevisible; Q86XT9; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR InterPro; IPR039493; TMEM248/TMEM219.
DR InterPro; IPR039587; TMEM248/TMEM219_dom.
DR PANTHER; PTHR16002; PTHR16002; 1.
DR Pfam; PF14940; TMEM219; 1.
PE 1: Evidence at protein level;
KW Apoptosis; Cell membrane; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..38
FT /evidence="ECO:0000255"
FT CHAIN 39..240
FT /note="Insulin-like growth factor-binding protein 3
FT receptor"
FT /id="PRO_0000329049"
FT TOPO_DOM 39..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 101
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 240 AA; 25724 MW; 8985EB036BB37EE8 CRC64;
MGNCQAGHNL HLCLAHHPPL VCATLILLLL GLSGLGLGSF LLTHRTGLRS PDIPQDWVSF
LRSFGQLTLC PRNGTVTGKW RGSHVVGLLT TLNFGDGPDR NKTRTFQATV LGSQMGLKGS
SAGQLVLITA RVTTERTAGT CLYFSAVPGI LPSSQPPISC SEEGAGNATL SPRMGEECVS
VWSHEGLVLT KLLTSEELAL CGSRLLVLGS FLLLFCGLLC CVTAMCFHPR RESHWSRTRL
