TM219_MOUSE
ID TM219_MOUSE Reviewed; 240 AA.
AC Q9D123; Q9D6H1;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Insulin-like growth factor-binding protein 3 receptor;
DE Short=IGFBP-3R;
DE AltName: Full=Transmembrane protein 219;
DE Flags: Precursor;
GN Name=Tmem219;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Cell death receptor specific for IGFBP3, may mediate caspase-
CC 8-dependent apoptosis upon ligand binding. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with IGFBP3. Interacts with CASP8 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane
CC protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D123-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D123-2; Sequence=VSP_032932, VSP_032933, VSP_032934;
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DR EMBL; AK004043; BAB23139.1; -; mRNA.
DR EMBL; AK013646; BAB28936.1; -; mRNA.
DR EMBL; AK152526; BAE31285.1; -; mRNA.
DR EMBL; BC023442; AAH23442.1; -; mRNA.
DR EMBL; BC046763; AAH46763.1; -; mRNA.
DR CCDS; CCDS40133.1; -. [Q9D123-1]
DR RefSeq; NP_081103.1; NM_026827.1. [Q9D123-1]
DR RefSeq; NP_082665.1; NM_028389.1. [Q9D123-1]
DR RefSeq; XP_006508220.1; XM_006508157.3.
DR RefSeq; XP_006508221.1; XM_006508158.3.
DR AlphaFoldDB; Q9D123; -.
DR IntAct; Q9D123; 1.
DR STRING; 10090.ENSMUSP00000032926; -.
DR GlyGen; Q9D123; 1 site.
DR PhosphoSitePlus; Q9D123; -.
DR MaxQB; Q9D123; -.
DR PaxDb; Q9D123; -.
DR PRIDE; Q9D123; -.
DR ProteomicsDB; 260686; -. [Q9D123-1]
DR ProteomicsDB; 260687; -. [Q9D123-2]
DR Antibodypedia; 68649; 10 antibodies from 7 providers.
DR Ensembl; ENSMUST00000032926; ENSMUSP00000032926; ENSMUSG00000060538. [Q9D123-1]
DR Ensembl; ENSMUST00000121532; ENSMUSP00000112485; ENSMUSG00000060538. [Q9D123-1]
DR GeneID; 68742; -.
DR KEGG; mmu:68742; -.
DR UCSC; uc009jtj.1; mouse. [Q9D123-1]
DR UCSC; uc009jtl.1; mouse. [Q9D123-2]
DR CTD; 124446; -.
DR MGI; MGI:1915992; Tmem219.
DR VEuPathDB; HostDB:ENSMUSG00000060538; -.
DR eggNOG; ENOG502S30C; Eukaryota.
DR GeneTree; ENSGT00940000153883; -.
DR InParanoid; Q9D123; -.
DR OrthoDB; 1408433at2759; -.
DR TreeFam; TF338507; -.
DR Reactome; R-MMU-6803211; TP53 Regulates Transcription of Death Receptors and Ligands.
DR BioGRID-ORCS; 68742; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Tmem219; mouse.
DR PRO; PR:Q9D123; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9D123; protein.
DR Bgee; ENSMUSG00000060538; Expressed in lacrimal gland and 211 other tissues.
DR ExpressionAtlas; Q9D123; baseline and differential.
DR Genevisible; Q9D123; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR InterPro; IPR039493; TMEM248/TMEM219.
DR InterPro; IPR039587; TMEM248/TMEM219_dom.
DR PANTHER; PTHR16002; PTHR16002; 1.
DR Pfam; PF14940; TMEM219; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Apoptosis; Cell membrane; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..38
FT /evidence="ECO:0000255"
FT CHAIN 39..240
FT /note="Insulin-like growth factor-binding protein 3
FT receptor"
FT /id="PRO_0000329050"
FT TOPO_DOM 39..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..71
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032932"
FT VAR_SEQ 196..198
FT /note="EEL -> VSA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032933"
FT VAR_SEQ 199..240
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032934"
SQ SEQUENCE 240 AA; 25573 MW; E3BBDE977F1A4952 CRC64;
MGSCQAGHNL HLCLAHHPPL VCATLILLLL GLSGLGLGGF LLTHTTGLRS PDIPQDWVSF
LRSFGQLSLC PMNETVTGTW QGPHVVGLLT TLNFGDGPDR NKTQTFQAKI HGSQIGLTGS
SAGESVLVTA RVASGRTPGT CLYFSGVPKV LPSSQPPISC SEEGVGNATL SPVMGEECVR
VWSHERLVLT ELLTSEELAL CGSRVLGLGF FLVLLCGLLC CTTAVCFHPR PEFHWSRTRL
