TM220_HUMAN
ID TM220_HUMAN Reviewed; 160 AA.
AC Q6QAJ8; A1YRJ4; B2RNE4; B4DJ52; B9EGW3;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Transmembrane protein 220;
GN Name=TMEM220;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Han Z., Hu X.;
RT "Homo sapiens mRNA similar to RIKEN cDNA A730055C05.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Yu Z., Zheng Z., Fu Y., Tang T.;
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Amygdala, and Substantia nigra;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6QAJ8; Q96PB8: LRRC3B; NbExp=3; IntAct=EBI-17963211, EBI-17775622;
CC Q6QAJ8; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-17963211, EBI-8638294;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6QAJ8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6QAJ8-2; Sequence=VSP_031477;
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DR EMBL; AY550194; AAS57719.1; -; mRNA.
DR EMBL; EF126147; ABL75442.1; -; mRNA.
DR EMBL; AK289624; BAF82313.1; -; mRNA.
DR EMBL; AK295928; BAG58714.1; -; mRNA.
DR EMBL; CH471108; EAW89993.1; -; Genomic_DNA.
DR EMBL; BC127705; AAI27706.1; -; mRNA.
DR EMBL; BC136838; AAI36839.1; -; mRNA.
DR EMBL; BC136840; AAI36841.1; -; mRNA.
DR CCDS; CCDS32567.1; -. [Q6QAJ8-1]
DR CCDS; CCDS82075.1; -. [Q6QAJ8-2]
DR RefSeq; NP_001004313.1; NM_001004313.1. [Q6QAJ8-1]
DR RefSeq; NP_001317068.1; NM_001330139.1. [Q6QAJ8-2]
DR RefSeq; NP_001317069.1; NM_001330140.1.
DR AlphaFoldDB; Q6QAJ8; -.
DR BioGRID; 132647; 12.
DR IntAct; Q6QAJ8; 7.
DR STRING; 9606.ENSP00000339830; -.
DR BioMuta; TMEM220; -.
DR DMDM; 74710017; -.
DR MassIVE; Q6QAJ8; -.
DR PaxDb; Q6QAJ8; -.
DR PeptideAtlas; Q6QAJ8; -.
DR PRIDE; Q6QAJ8; -.
DR ProteomicsDB; 67281; -. [Q6QAJ8-1]
DR ProteomicsDB; 67282; -. [Q6QAJ8-2]
DR Antibodypedia; 62490; 9 antibodies from 5 providers.
DR DNASU; 388335; -.
DR Ensembl; ENST00000341871.8; ENSP00000339830.4; ENSG00000187824.9. [Q6QAJ8-1]
DR Ensembl; ENST00000455996.6; ENSP00000396973.2; ENSG00000187824.9. [Q6QAJ8-2]
DR GeneID; 388335; -.
DR KEGG; hsa:388335; -.
DR MANE-Select; ENST00000341871.8; ENSP00000339830.4; NM_001004313.3; NP_001004313.1.
DR UCSC; uc002gmx.4; human. [Q6QAJ8-1]
DR CTD; 388335; -.
DR DisGeNET; 388335; -.
DR GeneCards; TMEM220; -.
DR HGNC; HGNC:33757; TMEM220.
DR HPA; ENSG00000187824; Tissue enhanced (liver).
DR neXtProt; NX_Q6QAJ8; -.
DR OpenTargets; ENSG00000187824; -.
DR PharmGKB; PA162406587; -.
DR VEuPathDB; HostDB:ENSG00000187824; -.
DR eggNOG; ENOG502S0TU; Eukaryota.
DR GeneTree; ENSGT00390000009386; -.
DR HOGENOM; CLU_135112_1_0_1; -.
DR InParanoid; Q6QAJ8; -.
DR OMA; LWVVVYM; -.
DR OrthoDB; 1569116at2759; -.
DR PhylomeDB; Q6QAJ8; -.
DR TreeFam; TF332092; -.
DR PathwayCommons; Q6QAJ8; -.
DR SignaLink; Q6QAJ8; -.
DR BioGRID-ORCS; 388335; 15 hits in 1078 CRISPR screens.
DR ChiTaRS; TMEM220; human.
DR GenomeRNAi; 388335; -.
DR Pharos; Q6QAJ8; Tdark.
DR PRO; PR:Q6QAJ8; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q6QAJ8; protein.
DR Bgee; ENSG00000187824; Expressed in right lobe of liver and 149 other tissues.
DR ExpressionAtlas; Q6QAJ8; baseline and differential.
DR Genevisible; Q6QAJ8; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029377; TMEM220.
DR Pfam; PF15071; TMEM220; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..160
FT /note="Transmembrane protein 220"
FT /id="PRO_0000319424"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 25..34
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.2"
FT /id="VSP_031477"
SQ SEQUENCE 160 AA; 17754 MW; 1E783D4C45D07D72 CRC64;
MAPALWRACN GLMAAFFALA ALVQVNDPDA EVWVVVYTIP AVLTLLVGLN PEVTGNVIWK
SISAIHILFC TVWAVGLASY LLHRTQQNIL HEEEGRELSG LVIITAWIIL CHSSSKNPVG
GRIQLAIAIV ITLFPFISWV YIYINKEMRS SWPTHCKTVI
