TM220_MOUSE
ID TM220_MOUSE Reviewed; 167 AA.
AC Q8BP07; Q2TB06; Q8C936;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Transmembrane protein 220;
GN Name=Tmem220;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Muellerian duct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BP07-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BP07-2; Sequence=VSP_031478;
CC Name=3;
CC IsoId=Q8BP07-3; Sequence=VSP_031479, VSP_031480;
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DR EMBL; AK043094; BAC31457.1; -; mRNA.
DR EMBL; AK078505; BAC37312.1; -; mRNA.
DR EMBL; AL645988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC110628; AAI10629.1; -; mRNA.
DR EMBL; BC110629; AAI10630.1; -; mRNA.
DR CCDS; CCDS24850.1; -. [Q8BP07-2]
DR CCDS; CCDS70209.1; -. [Q8BP07-1]
DR RefSeq; NP_001277971.1; NM_001291042.1. [Q8BP07-1]
DR RefSeq; NP_001277972.1; NM_001291043.1. [Q8BP07-3]
DR RefSeq; NP_796366.1; NM_177392.3. [Q8BP07-2]
DR AlphaFoldDB; Q8BP07; -.
DR PeptideAtlas; Q8BP07; -.
DR PRIDE; Q8BP07; -.
DR ProteomicsDB; 259550; -. [Q8BP07-1]
DR ProteomicsDB; 259551; -. [Q8BP07-2]
DR ProteomicsDB; 259552; -. [Q8BP07-3]
DR Antibodypedia; 62490; 9 antibodies from 5 providers.
DR DNASU; 338369; -.
DR Ensembl; ENSMUST00000061786; ENSMUSP00000057366; ENSMUSG00000050270. [Q8BP07-1]
DR Ensembl; ENSMUST00000079077; ENSMUSP00000078084; ENSMUSG00000050270. [Q8BP07-2]
DR GeneID; 338369; -.
DR KEGG; mmu:338369; -.
DR UCSC; uc007jlp.2; mouse. [Q8BP07-2]
DR UCSC; uc007jlq.2; mouse. [Q8BP07-3]
DR UCSC; uc007jlr.2; mouse. [Q8BP07-1]
DR CTD; 388335; -.
DR MGI; MGI:2443691; Tmem220.
DR VEuPathDB; HostDB:ENSMUSG00000050270; -.
DR GeneTree; ENSGT00390000009386; -.
DR HOGENOM; CLU_135112_1_0_1; -.
DR InParanoid; Q8BP07; -.
DR OMA; LWVVVYM; -.
DR OrthoDB; 1569116at2759; -.
DR PhylomeDB; Q8BP07; -.
DR TreeFam; TF332092; -.
DR BioGRID-ORCS; 338369; 4 hits in 73 CRISPR screens.
DR PRO; PR:Q8BP07; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8BP07; protein.
DR Bgee; ENSMUSG00000050270; Expressed in liver and 53 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029377; TMEM220.
DR Pfam; PF15071; TMEM220; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..167
FT /note="Transmembrane protein 220"
FT /id="PRO_0000319425"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 41
FT /note="V -> VTRKSFCRESLYQRLPLPMTTPGMT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031478"
FT VAR_SEQ 103..107
FT /note="RELSG -> SCLAW (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031479"
FT VAR_SEQ 108..167
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031480"
SQ SEQUENCE 167 AA; 18324 MW; 56B18EE2E0C18797 CRC64;
MAPAVATWAP GLWRACNALM AAFFALAAVV QVNDPDAELW VVVYMIPAVL TLLVGFNPLV
TGNFIWKSVS AIHMLFCALW AGGLAYHFLL HAKQNLLNEE EGRELSGLVI VTAWMALCHS
SSKNPGGGRM HLAIAVVITL LPLLSWVYVH MNKEMRSSWP THCKTVI
