ID   TM221_HUMAN             Reviewed;         291 AA.
AC   A6NGB7;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2012, sequence version 3.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Transmembrane protein 221;
GN   Name=TMEM221;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AC010319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS54230.1; -.
DR   RefSeq; NP_001177773.1; NM_001190844.1.
DR   AlphaFoldDB; A6NGB7; -.
DR   BioGRID; 934747; 1.
DR   IntAct; A6NGB7; 1.
DR   STRING; 9606.ENSP00000342162; -.
DR   BioMuta; TMEM221; -.
DR   jPOST; A6NGB7; -.
DR   MassIVE; A6NGB7; -.
DR   PaxDb; A6NGB7; -.
DR   PeptideAtlas; A6NGB7; -.
DR   PRIDE; A6NGB7; -.
DR   ProteomicsDB; 1114; -.
DR   Antibodypedia; 51527; 17 antibodies from 9 providers.
DR   DNASU; 100130519; -.
DR   Ensembl; ENST00000341130.6; ENSP00000342162.5; ENSG00000188051.7.
DR   GeneID; 100130519; -.
DR   KEGG; hsa:100130519; -.
DR   MANE-Select; ENST00000341130.6; ENSP00000342162.5; NM_001190844.2; NP_001177773.1.
DR   UCSC; uc021uqh.1; human.
DR   CTD; 100130519; -.
DR   GeneCards; TMEM221; -.
DR   HGNC; HGNC:21943; TMEM221.
DR   HPA; ENSG00000188051; Tissue enhanced (ovary, retina).
DR   neXtProt; NX_A6NGB7; -.
DR   VEuPathDB; HostDB:ENSG00000188051; -.
DR   eggNOG; ENOG502RTGK; Eukaryota.
DR   GeneTree; ENSGT00390000001907; -.
DR   HOGENOM; CLU_079663_0_0_1; -.
DR   InParanoid; A6NGB7; -.
DR   OMA; CPRMHRT; -.
DR   OrthoDB; 1322590at2759; -.
DR   PhylomeDB; A6NGB7; -.
DR   TreeFam; TF336085; -.
DR   PathwayCommons; A6NGB7; -.
DR   SignaLink; A6NGB7; -.
DR   BioGRID-ORCS; 100130519; 18 hits in 1070 CRISPR screens.
DR   ChiTaRS; TMEM221; human.
DR   GenomeRNAi; 100130519; -.
DR   Pharos; A6NGB7; Tdark.
DR   PRO; PR:A6NGB7; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; A6NGB7; protein.
DR   Bgee; ENSG00000188051; Expressed in ventricular zone and 91 other tissues.
DR   Genevisible; A6NGB7; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR029201; Jiraiya.
DR   Pfam; PF15038; Jiraiya; 1.
PE   4: Predicted;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..291
FT                   /note="Transmembrane protein 221"
FT                   /id="PRO_0000332134"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          189..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   291 AA;  30293 MW;  99DAFE4307961118 CRC64;
     MARSYGGRVL AAMTLLGIAA AVLAALGAQL LFQLQAGRAE LRGLRAEGLG QELGAGPGLP
     EDAAGTLLPL AAALAALVLV LGFTCLLLAA LCGHLGAELA RGPGPRRSDW FLYDCRLLRH
     VALGLFCCGI SVYLAALSIY ALLLFEIETG AAAASILGSG TLVLVAVLTH TLLRAARAAR
     RGLHELSPPS FEDDLARPAE VSKASPRAQP QQGIHRRTPY STCPEPGDPF GSMATATAPA
     ALEGGWESSL PASRMHRTLS AGLGHWDGVT HEMRRMLGHR PGSMGKDSTL V