ID   BST24_CAEEL             Reviewed;         632 AA.
AC   P34672;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Bestrophin homolog 24;
GN   Name=best-24; ORFNames=ZK688.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Forms chloride channels. {ECO:0000250}.
CC   -!- SUBUNIT: Forms oligomers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bestrophin family. {ECO:0000305}.
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DR   EMBL; FO080277; CCD62533.1; -; Genomic_DNA.
DR   PIR; S44917; S44917.
DR   RefSeq; NP_498717.1; NM_066316.5.
DR   AlphaFoldDB; P34672; -.
DR   SMR; P34672; -.
DR   BioGRID; 41317; 1.
DR   IntAct; P34672; 1.
DR   MINT; P34672; -.
DR   STRING; 6239.ZK688.2; -.
DR   iPTMnet; P34672; -.
DR   EPD; P34672; -.
DR   PaxDb; P34672; -.
DR   PeptideAtlas; P34672; -.
DR   EnsemblMetazoa; ZK688.2.1; ZK688.2.1; WBGene00022797.
DR   GeneID; 176110; -.
DR   KEGG; cel:CELE_ZK688.2; -.
DR   UCSC; ZK688.2; c. elegans.
DR   CTD; 176110; -.
DR   WormBase; ZK688.2; CE00460; WBGene00022797; best-24.
DR   eggNOG; KOG3547; Eukaryota.
DR   GeneTree; ENSGT00940000168986; -.
DR   HOGENOM; CLU_439573_0_0_1; -.
DR   InParanoid; P34672; -.
DR   OMA; FERIVQY; -.
DR   OrthoDB; 279144at2759; -.
DR   PhylomeDB; P34672; -.
DR   Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR   PRO; PR:P34672; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00022797; Expressed in larva and 2 other tissues.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR   InterPro; IPR000615; Bestrophin.
DR   InterPro; IPR021134; Bestrophin/UPF0187.
DR   PANTHER; PTHR10736; PTHR10736; 1.
DR   Pfam; PF01062; Bestrophin; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chloride; Chloride channel; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..632
FT                   /note="Bestrophin homolog 24"
FT                   /id="PRO_0000143135"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          491..516
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          562..632
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        491..508
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        562..603
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        613..632
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   632 AA;  73829 MW;  0ABDD1755EF11642 CRC64;
     MTINYNLAVS TSKPWTLFKL LLKWRGSIWK AVILELAVWL VLYGILSVIY RTALNPGQQR
     TFERIVQYCD SRLSYIPLNF MLGFFVTAVV NRWTYLYQII GFIDNIGLMA AEYVRGRTEQ
     ARMYRRNIVR YCELAQVLVF RDISMRTRRR FPTLDTVVAA GFMMPHEKDR FDEIQYKYSK
     YWVPFQWAFS LTYEARKKGL IESDYYQVVV QDEIKKFRTG LAWICNYDWV PIPIMYPQLV
     CLAVHTYFLV CLLARQYVVS EHADNKTEID LYFPIMSTLQ FIFYMGWMKV AEAMLNPFGE
     DDDDFECNAL IDRNITMVLM MVDQGYDRAP DLKRDDFWDE EVEPLYSEET AKIPNNPLKG
     SVSDVKLPEY VHEIKMVPHC DDASPLVPGD EMRRRRVSVV PVKPSDQQHH HHGHRTRTSL
     GNIEMFRSFK NKIERSFSKP HLHDDLGRKT FSHGMLENME FEGSNTNIAD GSHANNNSFT
     NSAFVNSGED LSNKRIDTSS SQPQLATGKR GSEHPFQHHV LDDVLEDDES DENQLTIRKK
     SSVLQPAITL VERFNEATGQ LETEVKRDEK KKKEEELREE GDNGKEEKDN KEDKKEEQDR
     PSRPTRPFFI GVVRSESEDH SHPHLRPPTK FE