ID   TM223_BOVIN             Reviewed;         202 AA.
AC   A5PJW2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Transmembrane protein 223 {ECO:0000305};
GN   Name=TMEM223 {ECO:0000250|UniProtKB:A0PJW6};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal brain;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial ribosome-associated protein involved in the
CC       first steps of cytochrome c oxidase complex (complex IV) biogenesis.
CC       Stimulates the translation of MT-CO1 mRNA and is a constituent of early
CC       MT-CO1 assembly intermediates. {ECO:0000250|UniProtKB:A0PJW6}.
CC   -!- SUBUNIT: Associates with the mitochondrial ribosome.
CC       {ECO:0000250|UniProtKB:A0PJW6}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:A0PJW6}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM223 family. {ECO:0000305}.
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DR   EMBL; BC142261; AAI42262.1; -; mRNA.
DR   RefSeq; NP_001093191.1; NM_001099721.2.
DR   AlphaFoldDB; A5PJW2; -.
DR   STRING; 9913.ENSBTAP00000012485; -.
DR   PaxDb; A5PJW2; -.
DR   PRIDE; A5PJW2; -.
DR   GeneID; 616632; -.
DR   KEGG; bta:616632; -.
DR   CTD; 79064; -.
DR   eggNOG; ENOG502S0RN; Eukaryota.
DR   InParanoid; A5PJW2; -.
DR   OrthoDB; 1478337at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR   InterPro; IPR026100; Tmem223.
DR   InterPro; IPR045325; TMEM70/TMEM186/TMEM223.
DR   PANTHER; PTHR14549; PTHR14549; 1.
DR   Pfam; PF06979; TMEM70; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..202
FT                   /note="Transmembrane protein 223"
FT                   /id="PRO_0000321832"
FT   TOPO_DOM        1..43
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:A0PJW6"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        65..97
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:A0PJW6"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..202
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:A0PJW6"
SQ   SEQUENCE   202 AA;  21992 MW;  647669E62D07B679 CRC64;
     MAAPGRRWSV LLFRALQSLS ARRALHDTAP PRDVLLFEHE RGRFFAVLGL FCAGQGVFWA
     SLAIASLARP PTPVRPTDAK TPDHGGLDLR STLWRYGLAV GCGAIGSLVL GAGLLFSLRS
     VRSVMLRAGG KQVTLTTHAP FGWGAHFTVP LNQVSCMAHR GEVPAMLPLK VKGRRFYFLL
     DKAGHFPNTK LFDNTVGAYR SL