ID   TM223_DANRE             Reviewed;         248 AA.
AC   Q6DC58;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Transmembrane protein 223 {ECO:0000305};
GN   Name=tmem223 {ECO:0000250|UniProtKB:A0PJW6};
GN   ORFNames=zgc:101024 {ECO:0000303|Ref.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial ribosome-associated protein involved in the
CC       first steps of cytochrome c oxidase complex (complex IV) biogenesis.
CC       Stimulates the translation of MT-CO1 mRNA and is a constituent of early
CC       MT-CO1 assembly intermediates. {ECO:0000250|UniProtKB:A0PJW6}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:A0PJW6}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM223 family. {ECO:0000305}.
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DR   EMBL; BC078226; AAH78226.1; -; mRNA.
DR   RefSeq; NP_001003594.1; NM_001003594.2.
DR   AlphaFoldDB; Q6DC58; -.
DR   PaxDb; Q6DC58; -.
DR   Ensembl; ENSDART00000101201; ENSDARP00000091975; ENSDARG00000069494.
DR   GeneID; 445200; -.
DR   KEGG; dre:445200; -.
DR   CTD; 79064; -.
DR   ZFIN; ZDB-GENE-040801-113; tmem223.
DR   eggNOG; ENOG502S0RN; Eukaryota.
DR   GeneTree; ENSGT00390000012589; -.
DR   HOGENOM; CLU_099187_0_0_1; -.
DR   InParanoid; Q6DC58; -.
DR   OMA; CMAHRDE; -.
DR   OrthoDB; 1478337at2759; -.
DR   PhylomeDB; Q6DC58; -.
DR   TreeFam; TF324862; -.
DR   PRO; PR:Q6DC58; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 21.
DR   Bgee; ENSDARG00000069494; Expressed in ovary and 22 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR   InterPro; IPR026100; Tmem223.
DR   InterPro; IPR045325; TMEM70/TMEM186/TMEM223.
DR   PANTHER; PTHR14549; PTHR14549; 1.
DR   Pfam; PF06979; TMEM70; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..248
FT                   /note="Transmembrane protein 223"
FT                   /id="PRO_0000360422"
FT   TRANSMEM        46..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   248 AA;  28081 MW;  27D588AB90BCCDBB CRC64;
     MAVQHLLFGV RRSCTFILAC RRTAFQSSRA FTSIYTQFKV TDTKNIFRPL VFPVRVASAF
     TFTSAAVAKD VLLFEHDRTR FFRLLAIFCG GQFLFWAYLG HFAFTSLRDT RKYSEPQKVR
     TELGGFFSFD MNLGSNAWRY GFTSGCLIIG GGILALALLF SRRSVSRVIL HKGGAKVSVY
     TQSPLGPQRS HHLTVPLSQV ACYAHRQESH SFIPLKVKGY KFYFLLDKEG TVNNPKLFDI
     TVGAYRPL