TM223_MOUSE
ID TM223_MOUSE Reviewed; 199 AA.
AC Q9CQE2;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Transmembrane protein 223 {ECO:0000305};
GN Name=Tmem223 {ECO:0000312|MGI:MGI:1914086};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Kidney, and Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Mitochondrial ribosome-associated protein involved in the
CC first steps of cytochrome c oxidase complex (complex IV) biogenesis.
CC Stimulates the translation of MT-CO1 mRNA and is a constituent of early
CC MT-CO1 assembly intermediates. {ECO:0000250|UniProtKB:A0PJW6}.
CC -!- SUBUNIT: Associates with the mitochondrial ribosome.
CC {ECO:0000250|UniProtKB:A0PJW6}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:A0PJW6}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TMEM223 family. {ECO:0000305}.
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DR EMBL; AK002249; BAB21964.1; -; mRNA.
DR EMBL; AK003417; BAB22778.1; -; mRNA.
DR EMBL; AK008282; BAB25573.1; -; mRNA.
DR EMBL; AK008327; BAB25605.1; -; mRNA.
DR EMBL; AK160470; BAE35807.1; -; mRNA.
DR EMBL; BC066781; AAH66781.1; -; mRNA.
DR CCDS; CCDS29544.1; -.
DR RefSeq; NP_080067.1; NM_025791.1.
DR AlphaFoldDB; Q9CQE2; -.
DR PhosphoSitePlus; Q9CQE2; -.
DR EPD; Q9CQE2; -.
DR MaxQB; Q9CQE2; -.
DR PaxDb; Q9CQE2; -.
DR PeptideAtlas; Q9CQE2; -.
DR PRIDE; Q9CQE2; -.
DR ProteomicsDB; 259553; -.
DR Antibodypedia; 3050; 8 antibodies from 7 providers.
DR DNASU; 66836; -.
DR Ensembl; ENSMUST00000010248; ENSMUSP00000010248; ENSMUSG00000117924.
DR GeneID; 66836; -.
DR KEGG; mmu:66836; -.
DR UCSC; uc008gms.1; mouse.
DR CTD; 79064; -.
DR MGI; MGI:1914086; Tmem223.
DR VEuPathDB; HostDB:ENSMUSG00000117924; -.
DR GeneTree; ENSGT00390000012589; -.
DR HOGENOM; CLU_099187_0_0_1; -.
DR InParanoid; Q9CQE2; -.
DR OMA; CMAHRDE; -.
DR OrthoDB; 1478337at2759; -.
DR PhylomeDB; Q9CQE2; -.
DR TreeFam; TF324862; -.
DR BioGRID-ORCS; 66836; 2 hits in 25 CRISPR screens.
DR ChiTaRS; Tmem223; mouse.
DR PRO; PR:Q9CQE2; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q9CQE2; protein.
DR Bgee; ENSMUSG00000117924; Expressed in midbrain and 61 other tissues.
DR Genevisible; Q9CQE2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR InterPro; IPR026100; Tmem223.
DR InterPro; IPR045325; TMEM70/TMEM186/TMEM223.
DR PANTHER; PTHR14549; PTHR14549; 1.
DR Pfam; PF06979; TMEM70; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..199
FT /note="Transmembrane protein 223"
FT /id="PRO_0000321834"
FT TOPO_DOM 1..43
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:A0PJW6"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..94
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:A0PJW6"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..199
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:A0PJW6"
SQ SEQUENCE 199 AA; 21857 MW; 992A84ACC159A5A1 CRC64;
MVASVPLRNV SHLLSVLRSQ NVPRYLQNGV PRDVLLFRHE RGRFFAILGL FCAGQGIFWT
SLAVAALSRP LSRVPAEAPN RSYQDLRSAL WRYGLAVGCG TMGVLVLGAG LLYSLRSVRS
VMLLAGGQQV TLTTYAPFGL GTCFTVPLNQ ISCMAHRGEV PAMLPLKVKG RRFYFLLDKA
GHFPNTQLFD NTVGAYRSL
