BST25_CAEEL
ID BST25_CAEEL Reviewed; 602 AA.
AC O18303;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2001, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Bestrophin homolog 25;
GN Name=best-25; ORFNames=ZK849.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Forms chloride channels. {ECO:0000250}.
CC -!- SUBUNIT: Forms oligomers. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the bestrophin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z82095; CAB05027.2; -; Genomic_DNA.
DR PIR; T28037; T28037.
DR RefSeq; NP_493479.1; NM_061078.1.
DR AlphaFoldDB; O18303; -.
DR SMR; O18303; -.
DR STRING; 6239.ZK849.4; -.
DR PaxDb; O18303; -.
DR EnsemblMetazoa; ZK849.4.1; ZK849.4.1; WBGene00014102.
DR GeneID; 191437; -.
DR KEGG; cel:CELE_ZK849.4; -.
DR UCSC; ZK849.4; c. elegans.
DR CTD; 191437; -.
DR WormBase; ZK849.4; CE25696; WBGene00014102; best-25.
DR eggNOG; KOG3547; Eukaryota.
DR GeneTree; ENSGT00970000195944; -.
DR HOGENOM; CLU_018069_7_1_1; -.
DR InParanoid; O18303; -.
DR OrthoDB; 279144at2759; -.
DR PhylomeDB; O18303; -.
DR Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR PRO; PR:O18303; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00014102; Expressed in adult organism and 1 other tissue.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR InterPro; IPR000615; Bestrophin.
DR InterPro; IPR021134; Bestrophin/UPF0187.
DR PANTHER; PTHR10736; PTHR10736; 1.
DR Pfam; PF01062; Bestrophin; 2.
PE 3: Inferred from homology;
KW Cell membrane; Chloride; Chloride channel; Ion channel; Ion transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..602
FT /note="Bestrophin homolog 25"
FT /id="PRO_0000143136"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 477..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..510
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 67608 MW; 458AB78802BD6B3A CRC64;
MHKVHIIYSR IFQMTVTYNR AVSTESIHNF VSIMSYWHGS LVKSIWKEYA IWIVLYHLIL
FIYRVVMPIF GWADYCKKVI ENWTPHQDMT IPLEFLLGFF VTTVIDRWRK AFQNIPYIEI
CAFAVAAAIP GRIRIINKKQ NEVRAPGGQD LRDVPAVEVN HPVQRGPEAP AAALPMPGAP
ERPAVALPMP GAPEGPAAIQ QPSVDVKLTA RRTIIRYLVL SQILLFREIS TKVKKRFVDL
KCLVDSKFLT DEELKILSKE VKCDHYDSYF LPINWAFSIL QEHKVKSNPE FINAWNVIRD
WQVKLSLLRN GDFIPIPLAY PQAVFLAIRF YFLVCLFTRQ HLDMDDKKSI DYYFPLMTSL
QFIFIVGWMK VAEILLNPMG EDDDDFELNN IIDKNLYIGL AIVDTECGKH PEIVKDTIGK
DCLPFYPQND DDNERNRALV GSTKNINLSG RSDTPAASPS VFYVNINVKV ENPTPVIVDG
ARPPPSPPAL PPALPNPNEP PPPPPPAEAL RADQPRHSLI HEVGAQADPA EANGAQALSP
VLPNPNERAD EHGHSPVIDN EAQPSPPPAE ANRAPIPNQQ PQVNGNAAPA SPRQAKVPDD
PH
