TM230_MOUSE
ID TM230_MOUSE Reviewed; 120 AA.
AC Q8CIB6; Q9CYF7;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Transmembrane protein 230;
GN Name=Tmem230;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic brain;
RX PubMed=15345747; DOI=10.1074/mcp.m400085-mcp200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=18630941; DOI=10.1021/pr800223m;
RA Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
RT "Specific phosphopeptide enrichment with immobilized titanium ion affinity
RT chromatography adsorbent for phosphoproteome analysis.";
RL J. Proteome Res. 7:3957-3967(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [8]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=27270108; DOI=10.1038/ng.3589;
RA Deng H.X., Shi Y., Yang Y., Ahmeti K.B., Miller N., Huang C., Cheng L.,
RA Zhai H., Deng S., Nuytemans K., Corbett N.J., Kim M.J., Deng H., Tang B.,
RA Yang Z., Xu Y., Chan P., Huang B., Gao X.P., Song Z., Liu Z., Fecto F.,
RA Siddique N., Foroud T., Jankovic J., Ghetti B., Nicholson D.A., Krainc D.,
RA Melen O., Vance J.M., Pericak-Vance M.A., Ma Y.C., Rajput A.H.,
RA Siddique T.;
RT "Identification of TMEM230 mutations in familial Parkinson's disease.";
RL Nat. Genet. 48:733-739(2016).
CC -!- FUNCTION: Involved in trafficking and recycling of synaptic vesicles.
CC {ECO:0000250|UniProtKB:Q96A57}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle {ECO:0000269|PubMed:27270108}. Golgi apparatus, trans-Golgi
CC network {ECO:0000250|UniProtKB:Q96A57}. Early endosome
CC {ECO:0000250|UniProtKB:Q96A57}. Recycling endosome
CC {ECO:0000250|UniProtKB:Q96A57}. Late endosome
CC {ECO:0000250|UniProtKB:Q96A57}. Cytoplasmic vesicle, autophagosome
CC {ECO:0000250|UniProtKB:Q96A57}.
CC -!- TISSUE SPECIFICITY: Widely expressed, including dopaminergic neurons in
CC the substantia nigra. {ECO:0000269|PubMed:27270108}.
CC -!- SIMILARITY: Belongs to the TMEM134/TMEM230 family. {ECO:0000305}.
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DR EMBL; AK170062; BAE41540.1; -; mRNA.
DR EMBL; AK017729; BAB30900.1; -; mRNA.
DR EMBL; BC033429; AAH33429.1; -; mRNA.
DR CCDS; CCDS16770.1; -.
DR RefSeq; NP_001135443.1; NM_001141971.1.
DR RefSeq; NP_081754.2; NM_027478.3.
DR RefSeq; XP_006500229.1; XM_006500166.3.
DR AlphaFoldDB; Q8CIB6; -.
DR STRING; 10090.ENSMUSP00000028816; -.
DR iPTMnet; Q8CIB6; -.
DR PhosphoSitePlus; Q8CIB6; -.
DR EPD; Q8CIB6; -.
DR jPOST; Q8CIB6; -.
DR MaxQB; Q8CIB6; -.
DR PaxDb; Q8CIB6; -.
DR PeptideAtlas; Q8CIB6; -.
DR PRIDE; Q8CIB6; -.
DR ProteomicsDB; 260688; -.
DR TopDownProteomics; Q8CIB6; -.
DR Antibodypedia; 2275; 186 antibodies from 23 providers.
DR DNASU; 70612; -.
DR Ensembl; ENSMUST00000028816; ENSMUSP00000028816; ENSMUSG00000027341.
DR Ensembl; ENSMUST00000110163; ENSMUSP00000105792; ENSMUSG00000027341.
DR Ensembl; ENSMUST00000110164; ENSMUSP00000105793; ENSMUSG00000027341.
DR Ensembl; ENSMUST00000180286; ENSMUSP00000136826; ENSMUSG00000027341.
DR GeneID; 70612; -.
DR KEGG; mmu:70612; -.
DR UCSC; uc008mmk.2; mouse.
DR CTD; 29058; -.
DR MGI; MGI:1917862; Tmem230.
DR VEuPathDB; HostDB:ENSMUSG00000027341; -.
DR eggNOG; KOG4753; Eukaryota.
DR GeneTree; ENSGT00390000008694; -.
DR HOGENOM; CLU_126638_1_0_1; -.
DR InParanoid; Q8CIB6; -.
DR OMA; AYYAYYK; -.
DR OrthoDB; 1557903at2759; -.
DR PhylomeDB; Q8CIB6; -.
DR TreeFam; TF329240; -.
DR BioGRID-ORCS; 70612; 5 hits in 71 CRISPR screens.
DR ChiTaRS; Tmem230; mouse.
DR PRO; PR:Q8CIB6; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8CIB6; protein.
DR Bgee; ENSMUSG00000027341; Expressed in spermatocyte and 61 other tissues.
DR Genevisible; Q8CIB6; MM.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005769; C:early endosome; ISS:UniProtKB.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005770; C:late endosome; ISS:UniProtKB.
DR GO; GO:0055037; C:recycling endosome; ISS:UniProtKB.
DR GO; GO:0008021; C:synaptic vesicle; ISS:UniProtKB.
DR GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR GO; GO:0048489; P:synaptic vesicle transport; ISS:UniProtKB.
DR InterPro; IPR044234; TMEM230.
DR InterPro; IPR008590; TMEM_230/134.
DR PANTHER; PTHR15664; PTHR15664; 1.
DR Pfam; PF05915; TMEM_230_134; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; Endosome; Golgi apparatus; Membrane; Phosphoprotein;
KW Reference proteome; Synapse; Transmembrane; Transmembrane helix.
FT CHAIN 1..120
FT /note="Transmembrane protein 230"
FT /id="PRO_0000233893"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 15
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96A57"
FT MOD_RES 24
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"
FT CONFLICT 86
FT /note="G -> R (in Ref. 1; BAB30900)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 120 AA; 13188 MW; 5F612C2B15D31E34 CRC64;
MMPSRTNLAT GLPSSKVKYS RLASTDDGYI DLQFKKSPPK IPYKAIALAT VLFLIGTFLI
IIGSLLLSGY ISKGGADRAV PVLIIGILVF LPGFYHLRIA YYASKGYRGY SYDDIPDFDD
