ID   TM230_RAT               Reviewed;         120 AA.
AC   Q5BJP5; Q0VGK9;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Transmembrane protein 230;
GN   Name=Tmem230;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver, and Thymus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=27270108; DOI=10.1038/ng.3589;
RA   Deng H.X., Shi Y., Yang Y., Ahmeti K.B., Miller N., Huang C., Cheng L.,
RA   Zhai H., Deng S., Nuytemans K., Corbett N.J., Kim M.J., Deng H., Tang B.,
RA   Yang Z., Xu Y., Chan P., Huang B., Gao X.P., Song Z., Liu Z., Fecto F.,
RA   Siddique N., Foroud T., Jankovic J., Ghetti B., Nicholson D.A., Krainc D.,
RA   Melen O., Vance J.M., Pericak-Vance M.A., Ma Y.C., Rajput A.H.,
RA   Siddique T.;
RT   "Identification of TMEM230 mutations in familial Parkinson's disease.";
RL   Nat. Genet. 48:733-739(2016).
CC   -!- FUNCTION: Involved in trafficking and recycling of synaptic vesicles.
CC       {ECO:0000250|UniProtKB:Q96A57}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, synaptic
CC       vesicle {ECO:0000269|PubMed:27270108}. Golgi apparatus, trans-Golgi
CC       network {ECO:0000250|UniProtKB:Q96A57}. Early endosome
CC       {ECO:0000250|UniProtKB:Q96A57}. Recycling endosome
CC       {ECO:0000250|UniProtKB:Q96A57}. Late endosome
CC       {ECO:0000250|UniProtKB:Q96A57}. Cytoplasmic vesicle, autophagosome
CC       {ECO:0000250|UniProtKB:Q96A57}.
CC   -!- SIMILARITY: Belongs to the TMEM134/TMEM230 family. {ECO:0000305}.
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DR   EMBL; BC091393; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC105614; AAI05615.1; -; mRNA.
DR   RefSeq; NP_001041508.1; NM_001048043.1.
DR   RefSeq; XP_006235132.1; XM_006235070.3.
DR   AlphaFoldDB; Q5BJP5; -.
DR   STRING; 10116.ENSRNOP00000028886; -.
DR   iPTMnet; Q5BJP5; -.
DR   PhosphoSitePlus; Q5BJP5; -.
DR   PaxDb; Q5BJP5; -.
DR   PRIDE; Q5BJP5; -.
DR   GeneID; 681315; -.
DR   KEGG; rno:681315; -.
DR   UCSC; RGD:1307399; rat.
DR   CTD; 29058; -.
DR   RGD; 1307399; Tmem230.
DR   eggNOG; KOG4753; Eukaryota.
DR   HOGENOM; CLU_126638_1_0_1; -.
DR   InParanoid; Q5BJP5; -.
DR   OMA; AYYAYYK; -.
DR   OrthoDB; 1557903at2759; -.
DR   PhylomeDB; Q5BJP5; -.
DR   TreeFam; TF329240; -.
DR   PRO; PR:Q5BJP5; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000021263; Expressed in stomach and 20 other tissues.
DR   Genevisible; Q5BJP5; RN.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005769; C:early endosome; ISS:UniProtKB.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; ISS:UniProtKB.
DR   GO; GO:0055037; C:recycling endosome; ISS:UniProtKB.
DR   GO; GO:0008021; C:synaptic vesicle; ISS:UniProtKB.
DR   GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR   GO; GO:0048489; P:synaptic vesicle transport; ISS:UniProtKB.
DR   InterPro; IPR044234; TMEM230.
DR   InterPro; IPR008590; TMEM_230/134.
DR   PANTHER; PTHR15664; PTHR15664; 1.
DR   Pfam; PF05915; TMEM_230_134; 1.
PE   1: Evidence at protein level;
KW   Cytoplasmic vesicle; Endosome; Golgi apparatus; Membrane; Phosphoprotein;
KW   Reference proteome; Synapse; Transmembrane; Transmembrane helix.
FT   CHAIN           1..120
FT                   /note="Transmembrane protein 230"
FT                   /id="PRO_0000233895"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         15
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96A57"
FT   MOD_RES         23
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96A57"
FT   MOD_RES         24
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   120 AA;  13204 MW;  73A3B93F465D22DE CRC64;
     MMPSRTNLAT GIPSSKVKYS RLSSTDDGYI DLQFKKSPPK IPYKAIALAT VLFLIGTFLI
     IIGSLLLSGY ISKGGADRAV PVLIIGILVF LPGFYHLRIA YYASKGYRGY SYDDIPDFDD