ID   TM231_BOVIN             Reviewed;         316 AA.
AC   A7MB75;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Transmembrane protein 231;
GN   Name=TMEM231;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transmembrane component of the tectonic-like complex, a
CC       complex localized at the transition zone of primary cilia and acting as
CC       a barrier that prevents diffusion of transmembrane proteins between the
CC       cilia and plasma membranes. Required for ciliogenesis and sonic
CC       hedgehog/SHH signaling (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC       Interacts with TMEM107. {ECO:0000250|UniProtKB:Q9H6L2}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}. Note=Localizes to the
CC       transition zone of primary cilia; SEPT2 is required for localization to
CC       the transition zone. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM231 family. {ECO:0000305}.
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DR   EMBL; BC151375; AAI51376.1; -; mRNA.
DR   RefSeq; NP_001094548.1; NM_001101078.1.
DR   AlphaFoldDB; A7MB75; -.
DR   STRING; 9913.ENSBTAP00000020510; -.
DR   PaxDb; A7MB75; -.
DR   Ensembl; ENSBTAT00000020510; ENSBTAP00000020510; ENSBTAG00000015432.
DR   GeneID; 511832; -.
DR   KEGG; bta:511832; -.
DR   CTD; 79583; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015432; -.
DR   VGNC; VGNC:52257; TMEM231.
DR   eggNOG; KOG4838; Eukaryota.
DR   GeneTree; ENSGT00390000015366; -.
DR   HOGENOM; CLU_070969_0_0_1; -.
DR   InParanoid; A7MB75; -.
DR   OMA; QLPARYH; -.
DR   OrthoDB; 1247968at2759; -.
DR   TreeFam; TF312969; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   ExpressionAtlas; A7MB75; baseline.
DR   GO; GO:0060170; C:ciliary membrane; ISS:UniProtKB.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0036038; C:MKS complex; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0032880; P:regulation of protein localization; IBA:GO_Central.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR019306; TMEM231.
DR   PANTHER; PTHR14605; PTHR14605; 1.
DR   Pfam; PF10149; TM231; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cilium; Cilium biogenesis/degradation;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..316
FT                   /note="Transmembrane protein 231"
FT                   /id="PRO_0000317519"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        194
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        199
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        221
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   316 AA;  36004 MW;  6BFB531E31DBC648 CRC64;
     MALYELFAHP VERGYRAGLC SKAALFLLLA TALTYIPPLL VAFRSHGFWL KRSSYEEQPT
     VRFQHQVLLV ALLGSEPGGF LAWSTFPAFN RLQEGHLRVP LVSAREEDRN QDGKMDMLHF
     KLELPLQSTE QVLGVQLILT FSYQLHRMST FVMQSMAFLQ SSFALPGSQL YVNGDLRLQQ
     KQPLGYGGLD VRYNVSVING TSPFASDYDL TRIVAAYQER NVTTILTDPS PIWLVGRAAE
     APFVVNAVIR YPVEVISYLP GFWEMIKFAW IQYVSILLIF LWAFERIKRF VFQNQVVTTI
     PVTAMPQGEL YKEHLS