TM231_CHICK
ID TM231_CHICK Reviewed; 320 AA.
AC F1NNL1;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 22-FEB-2012, sequence version 2.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Transmembrane protein 231;
GN Name=TMEM231;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red jungle fowl;
RX PubMed=15592404; DOI=10.1038/nature03154;
RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA Wilson R.K.;
RT "Sequence and comparative analysis of the chicken genome provide unique
RT perspectives on vertebrate evolution.";
RL Nature 432:695-716(2004).
CC -!- FUNCTION: Transmembrane component of the tectonic-like complex, a
CC complex localized at the transition zone of primary cilia and acting as
CC a barrier that prevents diffusion of transmembrane proteins between the
CC cilia and plasma membranes. Required for ciliogenesis and sonic
CC hedgehog/SHH signaling (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}. Note=Localizes to the
CC transition zone of primary cilia; SEPT2 is required for localization to
CC the transition zone. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TMEM231 family. {ECO:0000305}.
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DR EMBL; AADN02054203; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001292078.1; NM_001305149.1.
DR AlphaFoldDB; F1NNL1; -.
DR STRING; 9031.ENSGALP00000005089; -.
DR PaxDb; F1NNL1; -.
DR Ensembl; ENSGALT00000090346; ENSGALP00000058774; ENSGALG00000003219.
DR GeneID; 425108; -.
DR KEGG; gga:425108; -.
DR CTD; 79583; -.
DR VEuPathDB; HostDB:geneid_425108; -.
DR eggNOG; KOG4838; Eukaryota.
DR GeneTree; ENSGT00390000015366; -.
DR HOGENOM; CLU_070969_0_0_1; -.
DR InParanoid; F1NNL1; -.
DR OMA; QLPARYH; -.
DR OrthoDB; 1247968at2759; -.
DR PRO; PR:F1NNL1; -.
DR Proteomes; UP000000539; Chromosome 11.
DR Bgee; ENSGALG00000003219; Expressed in kidney and 13 other tissues.
DR ExpressionAtlas; F1NNL1; baseline and differential.
DR GO; GO:0060170; C:ciliary membrane; ISS:UniProtKB.
DR GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0036038; C:MKS complex; ISS:UniProtKB.
DR GO; GO:0043010; P:camera-type eye development; IEA:Ensembl.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
DR GO; GO:0060563; P:neuroepithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0032880; P:regulation of protein localization; IBA:GO_Central.
DR GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR GO; GO:0001944; P:vasculature development; IEA:Ensembl.
DR InterPro; IPR019306; TMEM231.
DR PANTHER; PTHR14605; PTHR14605; 1.
DR Pfam; PF10149; TM231; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cell projection; Cilium; Cilium biogenesis/degradation;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..320
FT /note="Transmembrane protein 231"
FT /id="PRO_0000415840"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 222
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 320 AA; 36527 MW; A733C9806DB3C534 CRC64;
MAGVELFSHP ALHTRYRAGL CSAAALALLL IAVLTYVPPL LVAYRSHGFW LKQSAYREQP
TVRFRYELLF VATTGPGPGS FLAWSTFPAF NRLQEDRLRV PLLSTREEDK NQDGKMDQLH
FKLELPLQPT EHVVGVQLIL IFSYQLYRMS TFVMQSMAFL QFFSPVPGSQ LYANGDLKLN
QRQLLNHCGL DTRYNVSVVN GTSPFASDYD LKNIIAAYRD RNVTTVFSDS NPIWMTGRGA
NTPFIVNATI RYPVEVILYQ PGFWETIKFA WIQYVSILLI FLWVFGRIKM FVFQNQVFAT
TPVSPVLPLS PVLSYKQHQP
