ID   BST26_CAEEL             Reviewed;         411 AA.
AC   O18304;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Bestrophin homolog 26;
GN   Name=best-26; ORFNames=ZK849.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Forms chloride channels. {ECO:0000250}.
CC   -!- SUBUNIT: Forms oligomers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bestrophin family. {ECO:0000305}.
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DR   EMBL; Z82095; CAB05028.1; -; Genomic_DNA.
DR   PIR; T28038; T28038.
DR   RefSeq; NP_493478.1; NM_061077.3.
DR   AlphaFoldDB; O18304; -.
DR   SMR; O18304; -.
DR   STRING; 6239.ZK849.5; -.
DR   PaxDb; O18304; -.
DR   PRIDE; O18304; -.
DR   EnsemblMetazoa; ZK849.5.1; ZK849.5.1; WBGene00014103.
DR   GeneID; 173291; -.
DR   KEGG; cel:CELE_ZK849.5; -.
DR   UCSC; ZK849.5; c. elegans.
DR   CTD; 173291; -.
DR   WormBase; ZK849.5; CE16750; WBGene00014103; best-26.
DR   eggNOG; KOG3547; Eukaryota.
DR   GeneTree; ENSGT00970000195944; -.
DR   HOGENOM; CLU_018069_0_1_1; -.
DR   InParanoid; O18304; -.
DR   OrthoDB; 279144at2759; -.
DR   PhylomeDB; O18304; -.
DR   Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR   PRO; PR:O18304; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00014103; Expressed in material anatomical entity and 2 other tissues.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR   InterPro; IPR000615; Bestrophin.
DR   InterPro; IPR021134; Bestrophin/UPF0187.
DR   PANTHER; PTHR10736; PTHR10736; 1.
DR   Pfam; PF01062; Bestrophin; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chloride; Chloride channel; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..411
FT                   /note="Bestrophin homolog 26"
FT                   /id="PRO_0000143137"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   411 AA;  48236 MW;  80FA40FEE2F166DB CRC64;
     MTVPYYRDVP TGNALRNFFK IMLKRKGNLF TAIFKELCLF LGLYFLFMVI YRLVLPKSGG
     QREIRKIVEN LLSHQEFTIP LEFLLGFFVS SVVDRWRKSL DSLAYIESCA HAVVIGFPPN
     SNGSDKNLLI RRTIIRYLVV SQILLYREIS LKVRRRFKKL TILGKAKLLN QNEIDKLNKL
     ECKHYDIYFL PISWALSLIE DKIDKENLAN EFTILWGQIK EWQTKLSLLR NCDYIPIPLA
     YPQAVFLAVR CYFAVCVFTR QHLDRYDSKM HTWITFFPVL TTFQYIFMMG WMKVAEILLN
     PMGEDEDDFE LNFIIDNNLK NGLDIVSGLC GNHRKLAEHE IENDCRPYYQ TNEQDRKKNR
     APPESLKNVE FKSFTMEKAS KDSPMVVKSE SVCCLRRRFN SSAKKHHDSK V