ID   TM231_PONAB             Reviewed;         316 AA.
AC   Q5RBT8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Transmembrane protein 231;
GN   Name=TMEM231;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transmembrane component of the tectonic-like complex, a
CC       complex localized at the transition zone of primary cilia and acting as
CC       a barrier that prevents diffusion of transmembrane proteins between the
CC       cilia and plasma membranes. Required for ciliogenesis and sonic
CC       hedgehog/SHH signaling (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC       Interacts with TMEM107. {ECO:0000250|UniProtKB:Q9H6L2}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}. Note=Localizes to the
CC       transition zone of primary cilia; SEPT2 is required for localization to
CC       the transition zone. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM231 family. {ECO:0000305}.
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DR   EMBL; CR858545; CAH90772.1; -; mRNA.
DR   RefSeq; NP_001125433.1; NM_001131961.2.
DR   AlphaFoldDB; Q5RBT8; -.
DR   STRING; 9601.ENSPPYP00000008537; -.
DR   GeneID; 100172341; -.
DR   KEGG; pon:100172341; -.
DR   CTD; 79583; -.
DR   eggNOG; KOG4838; Eukaryota.
DR   InParanoid; Q5RBT8; -.
DR   OrthoDB; 1247968at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0060170; C:ciliary membrane; ISS:UniProtKB.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0036038; C:MKS complex; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR019306; TMEM231.
DR   PANTHER; PTHR14605; PTHR14605; 1.
DR   Pfam; PF10149; TM231; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cilium; Cilium biogenesis/degradation;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..316
FT                   /note="Transmembrane protein 231"
FT                   /id="PRO_0000317522"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        194
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        199
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        221
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   316 AA;  35945 MW;  C65BCC8F293594B6 CRC64;
     MALYELFSHP VERSYRAGLC SKAALFLLLA AALTYIPPLL VAFRSHGFWL KRSSYEEQPT
     VRFQHQVLLV ALLGPESGGF LAWSTFPAFN RLQGDRLRVP LVSTREEDRN QDGKMDMLHF
     KLELPLQSTE HVLGVQLILT FSYQLHRMAT PVMQSMAFLQ SSFPVPGSQL YVNGDLRLQQ
     KQPLSCGGLD ARYNVSVING TSPFAYDYDL THVIAAYQER NVTTILNDPN PIWLVGRAAD
     APFVINAIIR YPVEVISYQP GFWEMVKFAW VQYVSILLIF VWVFERIKIF VFQNQVVTTI
     PVTATPRGEV CKEHLS