ID   TM231_RAT               Reviewed;         315 AA.
AC   Q5FVM1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Transmembrane protein 231;
GN   Name=Tmem231;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Transmembrane component of the tectonic-like complex, a
CC       complex localized at the transition zone of primary cilia and acting as
CC       a barrier that prevents diffusion of transmembrane proteins between the
CC       cilia and plasma membranes. Required for ciliogenesis and sonic
CC       hedgehog/SHH signaling (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC       Interacts with TMEM107. {ECO:0000250|UniProtKB:Q9H6L2}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}. Note=Localizes to the
CC       transition zone of primary cilia; SEPT2 is required for localization to
CC       the transition zone. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM231 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH89891.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC089891; AAH89891.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001257960.1; NM_001271031.1.
DR   AlphaFoldDB; Q5FVM1; -.
DR   STRING; 10116.ENSRNOP00000029280; -.
DR   GlyGen; Q5FVM1; 3 sites.
DR   PhosphoSitePlus; Q5FVM1; -.
DR   jPOST; Q5FVM1; -.
DR   PaxDb; Q5FVM1; -.
DR   GeneID; 361410; -.
DR   KEGG; rno:361410; -.
DR   UCSC; RGD:1306153; rat.
DR   CTD; 79583; -.
DR   RGD; 1306153; Tmem231.
DR   VEuPathDB; HostDB:ENSRNOG00000021517; -.
DR   eggNOG; KOG4838; Eukaryota.
DR   HOGENOM; CLU_070969_0_0_1; -.
DR   InParanoid; Q5FVM1; -.
DR   OMA; QLPARYH; -.
DR   OrthoDB; 1247968at2759; -.
DR   PhylomeDB; Q5FVM1; -.
DR   PRO; PR:Q5FVM1; -.
DR   Proteomes; UP000002494; Chromosome 19.
DR   Bgee; ENSRNOG00000021517; Expressed in testis and 19 other tissues.
DR   ExpressionAtlas; Q5FVM1; baseline and differential.
DR   Genevisible; Q5FVM1; RN.
DR   GO; GO:0060170; C:ciliary membrane; ISS:UniProtKB.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; ISO:RGD.
DR   GO; GO:0036038; C:MKS complex; ISS:UniProtKB.
DR   GO; GO:0043010; P:camera-type eye development; ISO:RGD.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0042733; P:embryonic digit morphogenesis; ISO:RGD.
DR   GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR   GO; GO:0060563; P:neuroepithelial cell differentiation; ISO:RGD.
DR   GO; GO:0032880; P:regulation of protein localization; ISO:RGD.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR   GO; GO:0001944; P:vasculature development; ISO:RGD.
DR   InterPro; IPR019306; TMEM231.
DR   PANTHER; PTHR14605; PTHR14605; 1.
DR   Pfam; PF10149; TM231; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cilium; Cilium biogenesis/degradation;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..315
FT                   /note="Transmembrane protein 231"
FT                   /id="PRO_0000317523"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        194
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        199
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        221
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   315 AA;  36170 MW;  5D917495FBE2918A CRC64;
     MALYHLFSHP IERAYRAGLC SKAALFLLLA TALTYIPPLL VAFRSHGFWL KRSNYEEQPN
     VRFQHQVLLV ALLGPEPGAF LAWSTYPTFN RLQGVHLRVP LVSTREEDRN QDGKMDVLYF
     KLELPLQSTE QVLGVQLILT FSYQLHRMST FEMQSMAFLQ SSFAVPGSQL HVNGDLRLQQ
     KQPLSYRGLD VRYNVSVING TSPFAHDYDL THIVAAYQER NVTTVLSDPN PIWLVGRAAE
     APFVIDAVIR YPVEVISYQP GFWEMIKFAW IQYVSILLIF LWVFERIKIF VFQNQVVTSI
     PVAVPQGEIR KEHLS