ID   TM231_XENTR             Reviewed;         312 AA.
AC   F7B645; B0JYY1; F6QSJ2;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Transmembrane protein 231;
GN   Name=tmem231;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transmembrane component of the tectonic-like complex, a
CC       complex localized at the transition zone of primary cilia and acting as
CC       a barrier that prevents diffusion of transmembrane proteins between the
CC       cilia and plasma membranes. Required for ciliogenesis and sonic
CC       hedgehog/SHH signaling (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}. Note=Localizes to the
CC       transition zone of primary cilia; SEPT2 is required for localization to
CC       the transition zone. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM231 family. {ECO:0000305}.
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DR   EMBL; AAMC01039122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC158962; AAI58963.1; -; mRNA.
DR   RefSeq; NP_001120108.1; NM_001126636.1.
DR   AlphaFoldDB; F7B645; -.
DR   STRING; 8364.ENSXETP00000007717; -.
DR   PaxDb; F7B645; -.
DR   GeneID; 100145127; -.
DR   KEGG; xtr:100145127; -.
DR   CTD; 79583; -.
DR   Xenbase; XB-GENE-1011804; tmem231.
DR   eggNOG; KOG4838; Eukaryota.
DR   HOGENOM; CLU_070969_0_0_1; -.
DR   InParanoid; F7B645; -.
DR   OMA; QLPARYH; -.
DR   OrthoDB; 1247968at2759; -.
DR   TreeFam; TF312969; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0060170; C:ciliary membrane; ISS:UniProtKB.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0036038; C:MKS complex; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0032880; P:regulation of protein localization; IBA:GO_Central.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR019306; TMEM231.
DR   PANTHER; PTHR14605; PTHR14605; 1.
DR   Pfam; PF10149; TM231; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cilium; Cilium biogenesis/degradation;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Transmembrane protein 231"
FT                   /id="PRO_0000415841"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        193
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        220
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        300
FT                   /note="S -> P (in Ref. 2; AAI58963)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   312 AA;  35820 MW;  BEB5B9B078E5082C CRC64;
     MALYEVYSHP ALLRYRSSIC SKATLFILIV LLLTYIPPLL VAFRSYGFWL KTSTYEEQPN
     VRFQYDVLLI ALSSTTGNYL AWSTYPGFNN LVGDKLRLPH ISAREEDRNQ DGKMDLLNFQ
     LELPLQPTDN IYGVQLILTF SYQLSKMSTF IMQSMALIQY SSPIPGSQLY MNGDLKLQQR
     QPLNHRGLDT TYNVSVINRS SPFASTYALT NIISSYQERN VTTVLNAPNP LWIVGRAASD
     PFVIKAVIRY PVESISYVPG FWEMLKYAWI QYVSILLIFL WVFERIKIFV FQNQVLTTVS
     GPIPSLYKSH QS