ID   TM232_HUMAN             Reviewed;         657 AA.
AC   C9JQI7; B4DKF4;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 2.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Transmembrane protein 232;
GN   Name=TMEM232;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Thalamus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=2;
CC         IsoId=C9JQI7-1; Sequence=Displayed;
CC       Name=1;
CC         IsoId=C9JQI7-2; Sequence=VSP_039352;
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DR   EMBL; AK296542; BAG59166.1; -; mRNA.
DR   EMBL; AC008650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC012622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC114290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471086; EAW49042.1; -; Genomic_DNA.
DR   CCDS; CCDS47253.2; -. [C9JQI7-1]
DR   RefSeq; NP_001034852.3; NM_001039763.3. [C9JQI7-1]
DR   RefSeq; XP_006714733.1; XM_006714670.3. [C9JQI7-1]
DR   RefSeq; XP_011541854.1; XM_011543552.2. [C9JQI7-1]
DR   RefSeq; XP_011541855.1; XM_011543553.2. [C9JQI7-1]
DR   RefSeq; XP_011541866.1; XM_011543564.2. [C9JQI7-2]
DR   RefSeq; XP_016865193.1; XM_017009704.1.
DR   AlphaFoldDB; C9JQI7; -.
DR   SMR; C9JQI7; -.
DR   BioGRID; 568408; 3.
DR   IntAct; C9JQI7; 2.
DR   MINT; C9JQI7; -.
DR   STRING; 9606.ENSP00000401477; -.
DR   iPTMnet; C9JQI7; -.
DR   PhosphoSitePlus; C9JQI7; -.
DR   BioMuta; TMEM232; -.
DR   MassIVE; C9JQI7; -.
DR   PaxDb; C9JQI7; -.
DR   PeptideAtlas; C9JQI7; -.
DR   PRIDE; C9JQI7; -.
DR   Antibodypedia; 57493; 17 antibodies from 9 providers.
DR   DNASU; 642987; -.
DR   Ensembl; ENST00000455884.7; ENSP00000401477.2; ENSG00000186952.15. [C9JQI7-1]
DR   GeneID; 642987; -.
DR   KEGG; hsa:642987; -.
DR   MANE-Select; ENST00000455884.7; ENSP00000401477.2; NM_001039763.4; NP_001034852.3.
DR   UCSC; uc011cvh.4; human. [C9JQI7-1]
DR   CTD; 642987; -.
DR   DisGeNET; 642987; -.
DR   GeneCards; TMEM232; -.
DR   HGNC; HGNC:37270; TMEM232.
DR   HPA; ENSG00000186952; Tissue enhanced (fallopian tube, testis).
DR   neXtProt; NX_C9JQI7; -.
DR   OpenTargets; ENSG00000186952; -.
DR   PharmGKB; PA165660571; -.
DR   VEuPathDB; HostDB:ENSG00000186952; -.
DR   eggNOG; ENOG502QVVE; Eukaryota.
DR   GeneTree; ENSGT00390000014003; -.
DR   HOGENOM; CLU_015366_1_0_1; -.
DR   InParanoid; C9JQI7; -.
DR   OMA; FFTRADR; -.
DR   OrthoDB; 679293at2759; -.
DR   PhylomeDB; C9JQI7; -.
DR   TreeFam; TF336968; -.
DR   PathwayCommons; C9JQI7; -.
DR   SignaLink; C9JQI7; -.
DR   BioGRID-ORCS; 642987; 9 hits in 1063 CRISPR screens.
DR   ChiTaRS; TMEM232; human.
DR   GenomeRNAi; 642987; -.
DR   Pharos; C9JQI7; Tdark.
DR   PRO; PR:C9JQI7; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; C9JQI7; protein.
DR   Bgee; ENSG00000186952; Expressed in bronchial epithelial cell and 109 other tissues.
DR   ExpressionAtlas; C9JQI7; baseline and differential.
DR   Genevisible; C9JQI7; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR031747; TMEM232.
DR   PANTHER; PTHR28651; PTHR28651; 1.
DR   Pfam; PF15877; TMEM232; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..657
FT                   /note="Transmembrane protein 232"
FT                   /id="PRO_0000395035"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        353..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         486..657
FT                   /note="AELNDPTDPFTRYSTNISSNVGEEVFSKYIGWRIANTLSKLFFPPIEAHFLP
FT                   LKKPSIKKDQTKYPNKKLESVKKQVLHFTVREHPSVSEIPMFPYPDFFTKADKELAKII
FT                   DHHWQEELKIREKEDAICKAQELKDKKLAEKNHFQEVMKKREEKLHKQTKPYELPYRKE
FT                   VI -> GTSFCIRNSHVSISRFLHQGR (in isoform 1)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_039352"
SQ   SEQUENCE   657 AA;  76453 MW;  1E6D0910A3422E1E CRC64;
     MNMPVNKSPM INTCGGISSP YHEELWKLNF QHLSGERGHK SRPTFSITKE FILRFNQTQN
     SKEKEELLEL ARKIILRCKR KLGLKTLGSG RHVHLPAAWT EVIYLAQCKG EIQDESLNML
     YASLDHASFD YDHLPALFFV AESVLYRLCC DASLKTYLYS VEIKLAKIGY LVFLRLFIFF
     LHGHLESFKQ HLLRLQPYLY ALSFSGASYH KYPNIFSNVQ FILKASEIIG KRELRSESIF
     RPVEDKKRYE NTDSDMGGYE INHLLWHCVA AWSCVQNNSP QLNNVLEHLV FHKTQLQKKC
     WLDSVLALLV LGEAAKLNMA CLKALMDVVR DFVSSIMSVQ NQEESCKVDD FSWAWNVVYI
     YTVILAEICL YAATSDLRKT ALIGFCHCKS SQKNILYLDK SVPPELKETS ILSLLEYFSS
     KMSENCDQVV WTGYYGLVYN LVKISWELQG DEEQDGLRNM IWQTLQKTKD YEEDVRIQNA
     INIAQAELND PTDPFTRYST NISSNVGEEV FSKYIGWRIA NTLSKLFFPP IEAHFLPLKK
     PSIKKDQTKY PNKKLESVKK QVLHFTVREH PSVSEIPMFP YPDFFTKADK ELAKIIDHHW
     QEELKIREKE DAICKAQELK DKKLAEKNHF QEVMKKREEK LHKQTKPYEL PYRKEVI