TM232_MOUSE
ID TM232_MOUSE Reviewed; 675 AA.
AC Q5K6N0; B2RX35; B7ZWG2; Q5K6N1;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Transmembrane protein 232;
DE AltName: Full=Testis-specific protein 13;
GN Name=Tmem232; Synonyms=Tes13;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RA Renu W., Sugihara T., Ando H.;
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=Tes13-L;
CC IsoId=Q5K6N0-1; Sequence=Displayed;
CC Name=2; Synonyms=Tes13-S;
CC IsoId=Q5K6N0-2; Sequence=VSP_039353;
CC Name=3;
CC IsoId=Q5K6N0-3; Sequence=VSP_039354;
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DR EMBL; AF338468; AAQ14894.1; -; mRNA.
DR EMBL; AF338469; AAQ14895.1; -; mRNA.
DR EMBL; BC150885; AAI50886.1; -; mRNA.
DR EMBL; BC172032; AAI72032.1; -; mRNA.
DR CCDS; CCDS28940.1; -. [Q5K6N0-1]
DR CCDS; CCDS89134.1; -. [Q5K6N0-3]
DR CCDS; CCDS89135.1; -. [Q5K6N0-2]
DR RefSeq; NP_001008973.2; NM_001008973.2. [Q5K6N0-1]
DR RefSeq; NP_001276414.1; NM_001289485.1. [Q5K6N0-1]
DR RefSeq; NP_001276415.1; NM_001289486.1. [Q5K6N0-3]
DR RefSeq; XP_006524554.1; XM_006524491.3.
DR AlphaFoldDB; Q5K6N0; -.
DR SMR; Q5K6N0; -.
DR STRING; 10090.ENSMUSP00000055652; -.
DR iPTMnet; Q5K6N0; -.
DR PhosphoSitePlus; Q5K6N0; -.
DR PaxDb; Q5K6N0; -.
DR PRIDE; Q5K6N0; -.
DR ProteomicsDB; 259409; -. [Q5K6N0-1]
DR ProteomicsDB; 259410; -. [Q5K6N0-2]
DR ProteomicsDB; 259411; -. [Q5K6N0-3]
DR Antibodypedia; 57493; 17 antibodies from 9 providers.
DR DNASU; 381107; -.
DR Ensembl; ENSMUST00000062161; ENSMUSP00000055652; ENSMUSG00000045036. [Q5K6N0-1]
DR Ensembl; ENSMUST00000086722; ENSMUSP00000083927; ENSMUSG00000045036. [Q5K6N0-1]
DR Ensembl; ENSMUST00000233117; ENSMUSP00000156833; ENSMUSG00000045036. [Q5K6N0-3]
DR Ensembl; ENSMUST00000233738; ENSMUSP00000156513; ENSMUSG00000045036. [Q5K6N0-2]
DR GeneID; 381107; -.
DR KEGG; mmu:381107; -.
DR UCSC; uc008dga.1; mouse. [Q5K6N0-1]
DR UCSC; uc012awg.1; mouse. [Q5K6N0-3]
DR CTD; 642987; -.
DR MGI; MGI:2685786; Tmem232.
DR VEuPathDB; HostDB:ENSMUSG00000045036; -.
DR eggNOG; ENOG502QVVE; Eukaryota.
DR GeneTree; ENSGT00390000014003; -.
DR HOGENOM; CLU_015366_1_0_1; -.
DR InParanoid; Q5K6N0; -.
DR OMA; FFTRADR; -.
DR OrthoDB; 679293at2759; -.
DR PhylomeDB; Q5K6N0; -.
DR TreeFam; TF336968; -.
DR BioGRID-ORCS; 381107; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Tmem232; mouse.
DR PRO; PR:Q5K6N0; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q5K6N0; protein.
DR Bgee; ENSMUSG00000045036; Expressed in dorsal pancreas and 44 other tissues.
DR ExpressionAtlas; Q5K6N0; baseline and differential.
DR Genevisible; Q5K6N0; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031747; TMEM232.
DR PANTHER; PTHR28651; PTHR28651; 1.
DR Pfam; PF15877; TMEM232; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..675
FT /note="Transmembrane protein 232"
FT /id="PRO_0000395036"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 605..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 598..634
FT /evidence="ECO:0000255"
FT VAR_SEQ 2..40
FT /note="KAYKPPVVNKFGVISSTYHEELLKSIFESSNRRKSQKPK -> TSKKW (in
FT isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_039353"
FT VAR_SEQ 113
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039354"
FT CONFLICT 3
FT /note="A -> V (in Ref. 1; AAQ14895)"
FT /evidence="ECO:0000305"
FT CONFLICT 95
FT /note="T -> P (in Ref. 1; AAQ14894/AAQ14895)"
FT /evidence="ECO:0000305"
FT CONFLICT 463
FT /note="M -> K (in Ref. 1; AAQ14894/AAQ14895)"
FT /evidence="ECO:0000305"
FT CONFLICT 481
FT /note="R -> Q (in Ref. 1; AAQ14894/AAQ14895)"
FT /evidence="ECO:0000305"
FT CONFLICT 501
FT /note="K -> E (in Ref. 1; AAQ14894/AAQ14895)"
FT /evidence="ECO:0000305"
FT CONFLICT 542
FT /note="V -> M (in Ref. 1; AAQ14894/AAQ14895)"
FT /evidence="ECO:0000305"
FT CONFLICT 556
FT /note="A -> S (in Ref. 1; AAQ14894/AAQ14895)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 675 AA; 78275 MW; 3E815C48A2934F33 CRC64;
MKAYKPPVVN KFGVISSTYH EELLKSIFES SNRRKSQKPK PSFSISKEFI LRFNHTDNPA
EEEELLEQAR RLIVRSKRKL GLKTLGSGKH VHLPTAWAEV IYLAQCKGEI QDEALNMLHA
SLDHVSFDHD QLPALFFLAE SVLYRLCCDA FMKGYLYSVE IKLVKIGYLI FLRLFVFFLH
GHLESFKQHL LRLQPYLYAL HFSEPSYYKY PNIISNVQFI LKTSEIICKR ELHSEPFVES
PDETEDPYSD LNHLQLNKRG YEVNHLLWHS VAAWSCVQNN RPQLTEVLEH LLFYKTQLQT
KCWLDSALAL MVLGEAAKLD MACLKTLMDL VTDFLENILS AQNQEENYNI YDTSWASEIV
FTYTTIIAEV CLYAATSDLR KTALIGFCAC KSPQQGISLT DKSEELPELD GASILTLLKY
FSSRISDNCE KVIWIGYYGI VYNLVKMSWE LQGEQDQDGL RNMIWQTLQK IKDYEQDPRI
RCALVIAQAE LNGPSDPFCT KATPNSGEEV FSKYIGWRIA TTLSRLFFPS LDVAPPKTPV
EVDLPRKHTI RERQPAKKRV LRFILKDHSS VVEVSMTPYP NFFTKADKKL EEIIDHHWQK
DMEARKREEE AYKAQNQKDK EEKEKIHFQE IMKQRERKLN KQTKPYEIIL SEKESGSEKK
CGFFELKPST APNAK
