ID   TM233_MOUSE             Reviewed;         110 AA.
AC   D3Z1U7;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 2.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Transmembrane protein 233;
DE   AltName: Full=Dispanin subfamily B member 2;
DE            Short=DSPB2;
GN   Name=Tmem233;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   GENE FAMILY.
RX   PubMed=22363774; DOI=10.1371/journal.pone.0031961;
RA   Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.;
RT   "The dispanins: a novel gene family of ancient origin that contains 14
RT   human members.";
RL   PLoS ONE 7:E31961-E31961(2012).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CD225/Dispanin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDL19832.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AC115795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466529; EDL19832.1; ALT_INIT; Genomic_DNA.
DR   CCDS; CCDS51629.1; -.
DR   RefSeq; NP_001095016.1; NM_001101546.1.
DR   AlphaFoldDB; D3Z1U7; -.
DR   STRING; 10090.ENSMUSP00000107628; -.
DR   PhosphoSitePlus; D3Z1U7; -.
DR   PaxDb; D3Z1U7; -.
DR   PRIDE; D3Z1U7; -.
DR   Ensembl; ENSMUST00000111997; ENSMUSP00000107628; ENSMUSG00000079278.
DR   GeneID; 545798; -.
DR   KEGG; mmu:545798; -.
DR   CTD; 387890; -.
DR   MGI; MGI:3651514; Tmem233.
DR   VEuPathDB; HostDB:ENSMUSG00000079278; -.
DR   eggNOG; ENOG502S62Q; Eukaryota.
DR   GeneTree; ENSGT00940000162372; -.
DR   InParanoid; D3Z1U7; -.
DR   OMA; NPIEMNG; -.
DR   OrthoDB; 1500473at2759; -.
DR   TreeFam; TF331357; -.
DR   BioGRID-ORCS; 545798; 1 hit in 72 CRISPR screens.
DR   ChiTaRS; Tmem233; mouse.
DR   PRO; PR:D3Z1U7; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; D3Z1U7; protein.
DR   Bgee; ENSMUSG00000079278; Expressed in skeletal muscle tissue and 9 other tissues.
DR   ExpressionAtlas; D3Z1U7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   InterPro; IPR007593; CD225/Dispanin_fam.
DR   Pfam; PF04505; CD225; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..110
FT                   /note="Transmembrane protein 233"
FT                   /id="PRO_0000394963"
FT   TOPO_DOM        1..42
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        64..85
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        107..110
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   110 AA;  11997 MW;  5B6CE965CE732CD1 CRC64;
     MSQYASRSDS KGALDSSSPE AYTEDDKTEE DIPAPSNYLW LTIISCFCPA YPVNIVALVF
     SIMSLNSYND GDYEGARRLG RNAKWVAIAS IIIGLVIIGV SCAVHFSRNP