TM234_HUMAN
ID TM234_HUMAN Reviewed; 164 AA.
AC Q8WY98; B2R535; D3DPP7; Q6UWY9; Q8N2H6; Q9BSR2; Q9NU76;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Transmembrane protein 234;
GN Name=TMEM234; Synonyms=C1orf91; ORFNames=PP1065, UNQ548/PRO1105;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 58-164 (ISOFORM 2).
RC TISSUE=Testis, and Thyroid;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
RC TISSUE=Brain, Cervix, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8WY98; Q13520: AQP6; NbExp=3; IntAct=EBI-8642211, EBI-13059134;
CC Q8WY98; Q6PL45-2: BRICD5; NbExp=3; IntAct=EBI-8642211, EBI-12244618;
CC Q8WY98; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-8642211, EBI-6942903;
CC Q8WY98; Q07325: CXCL9; NbExp=3; IntAct=EBI-8642211, EBI-3911467;
CC Q8WY98; Q96D05-2: FAM241B; NbExp=3; IntAct=EBI-8642211, EBI-12118888;
CC Q8WY98; Q14973: SLC10A1; NbExp=3; IntAct=EBI-8642211, EBI-3923031;
CC Q8WY98; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-8642211, EBI-18159983;
CC Q8WY98; Q8N130: SLC34A3; NbExp=3; IntAct=EBI-8642211, EBI-17769653;
CC Q8WY98; Q7Z769: SLC35E3; NbExp=3; IntAct=EBI-8642211, EBI-13389236;
CC Q8WY98; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-8642211, EBI-10226799;
CC Q8WY98; Q6UX40: TMEM107; NbExp=3; IntAct=EBI-8642211, EBI-12845616;
CC Q8WY98; Q969S6: TMEM203; NbExp=3; IntAct=EBI-8642211, EBI-12274070;
CC Q8WY98; A2RU14: TMEM218; NbExp=3; IntAct=EBI-8642211, EBI-10173151;
CC Q8WY98; Q53HI1: UNC50; NbExp=3; IntAct=EBI-8642211, EBI-7601760;
CC Q8WY98; Q9UEU0: VTI1B; NbExp=3; IntAct=EBI-8642211, EBI-723716;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8WY98-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WY98-2; Sequence=VSP_028107;
CC Name=3;
CC IsoId=Q8WY98-3; Sequence=VSP_028108, VSP_028109;
CC Name=4;
CC IsoId=Q8WY98-4; Sequence=VSP_028105, VSP_028106;
CC -!- MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM234 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC11504.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY358586; AAQ88949.1; -; mRNA.
DR EMBL; AK075260; BAC11504.1; ALT_INIT; mRNA.
DR EMBL; AK312046; BAG34982.1; -; mRNA.
DR EMBL; AF258548; AAG23751.1; -; mRNA.
DR EMBL; AL049795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471059; EAX07556.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX07559.1; -; Genomic_DNA.
DR EMBL; BC001256; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CH471059; EAX07557.1; -; Genomic_DNA.
DR EMBL; BC004885; AAH04885.1; -; mRNA.
DR EMBL; BC038842; AAH38842.1; -; mRNA.
DR CCDS; CCDS356.2; -. [Q8WY98-3]
DR RefSeq; NP_061991.3; NM_019118.4. [Q8WY98-3]
DR RefSeq; XP_016857301.1; XM_017001812.1. [Q8WY98-2]
DR RefSeq; XP_016857302.1; XM_017001813.1. [Q8WY98-2]
DR RefSeq; XP_016857306.1; XM_017001817.1.
DR RefSeq; XP_016857307.1; XM_017001818.1.
DR RefSeq; XP_016857308.1; XM_017001819.1.
DR RefSeq; XP_016857309.1; XM_017001820.1.
DR RefSeq; XP_016857310.1; XM_017001821.1.
DR RefSeq; XP_016857311.1; XM_017001822.1.
DR RefSeq; XP_016857312.1; XM_017001823.1.
DR RefSeq; XP_016857313.1; XM_017001824.1.
DR RefSeq; XP_016857315.1; XM_017001826.1.
DR RefSeq; XP_016857316.1; XM_017001827.1. [Q8WY98-3]
DR RefSeq; XP_016857317.1; XM_017001828.1. [Q8WY98-3]
DR RefSeq; XP_016857318.1; XM_017001829.1.
DR RefSeq; XP_016857319.1; XM_017001830.1. [Q8WY98-3]
DR AlphaFoldDB; Q8WY98; -.
DR BioGRID; 121036; 19.
DR IntAct; Q8WY98; 18.
DR MINT; Q8WY98; -.
DR STRING; 9606.ENSP00000309792; -.
DR TCDB; 2.A.7.32.1; the drug/metabolite transporter (dmt) superfamily.
DR iPTMnet; Q8WY98; -.
DR BioMuta; TMEM234; -.
DR DMDM; 74760615; -.
DR MassIVE; Q8WY98; -.
DR MaxQB; Q8WY98; -.
DR PaxDb; Q8WY98; -.
DR PeptideAtlas; Q8WY98; -.
DR PRIDE; Q8WY98; -.
DR ProteomicsDB; 75136; -. [Q8WY98-1]
DR ProteomicsDB; 75137; -. [Q8WY98-2]
DR ProteomicsDB; 75138; -. [Q8WY98-3]
DR ProteomicsDB; 75139; -. [Q8WY98-4]
DR Antibodypedia; 3093; 9 antibodies from 7 providers.
DR DNASU; 56063; -.
DR Ensembl; ENST00000309777.11; ENSP00000309792.6; ENSG00000160055.20. [Q8WY98-3]
DR Ensembl; ENST00000344461.7; ENSP00000344021.3; ENSG00000160055.20. [Q8WY98-1]
DR Ensembl; ENST00000373593.5; ENSP00000362695.1; ENSG00000160055.20. [Q8WY98-2]
DR Ensembl; ENST00000461402.5; ENSP00000433020.1; ENSG00000160055.20. [Q8WY98-1]
DR Ensembl; ENST00000483001.5; ENSP00000434295.1; ENSG00000160055.20. [Q8WY98-1]
DR Ensembl; ENST00000489170.5; ENSP00000436631.1; ENSG00000160055.20. [Q8WY98-1]
DR Ensembl; ENST00000491434.5; ENSP00000435588.1; ENSG00000160055.20. [Q8WY98-4]
DR GeneID; 56063; -.
DR KEGG; hsa:56063; -.
DR MANE-Select; ENST00000309777.11; ENSP00000309792.6; NM_019118.5; NP_061991.3. [Q8WY98-3]
DR UCSC; uc001buo.4; human. [Q8WY98-1]
DR CTD; 56063; -.
DR GeneCards; TMEM234; -.
DR HGNC; HGNC:28837; TMEM234.
DR HPA; ENSG00000160055; Low tissue specificity.
DR neXtProt; NX_Q8WY98; -.
DR OpenTargets; ENSG00000160055; -.
DR PharmGKB; PA142672475; -.
DR VEuPathDB; HostDB:ENSG00000160055; -.
DR eggNOG; KOG4831; Eukaryota.
DR GeneTree; ENSGT00940000162781; -.
DR HOGENOM; CLU_2359081_0_0_1; -.
DR InParanoid; Q8WY98; -.
DR OMA; GLQQVHE; -.
DR PhylomeDB; Q8WY98; -.
DR TreeFam; TF300180; -.
DR PathwayCommons; Q8WY98; -.
DR SignaLink; Q8WY98; -.
DR BioGRID-ORCS; 56063; 16 hits in 1086 CRISPR screens.
DR ChiTaRS; TMEM234; human.
DR GenomeRNAi; 56063; -.
DR Pharos; Q8WY98; Tdark.
DR PRO; PR:Q8WY98; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8WY98; protein.
DR Bgee; ENSG00000160055; Expressed in right uterine tube and 151 other tissues.
DR ExpressionAtlas; Q8WY98; baseline and differential.
DR Genevisible; Q8WY98; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018908; TMEM234.
DR PANTHER; PTHR28668; PTHR28668; 1.
DR Pfam; PF10639; TMEM234; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..164
FT /note="Transmembrane protein 234"
FT /id="PRO_0000304697"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 79..96
FT /note="DLTLAVPICNSLAIIFTL -> GWSQTSEFRSSCWNPGKH (in isoform
FT 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028105"
FT VAR_SEQ 97..164
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028106"
FT VAR_SEQ 111..164
FT /note="AVAGMVLTVIGISLCITSSVPWTAELQLHGKGQLQTLSQKCKREASGTQSER
FT FG -> KLDYCECGTQLCGSRHTCVSSFPEPISPEWVRTRPFPILPFPLQLFCFLVAIR
FT VPFPWTVWRKTEAGVWD (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_028107"
FT VAR_SEQ 131..140
FT /note="PWTAELQLHG -> SKTQGQQSTL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028108"
FT VAR_SEQ 141..164
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028109"
FT CONFLICT 66
FT /note="C -> R (in Ref. 2; BAC11504)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 164 AA; 17601 MW; 40EEF55C8FC80777 CRC64;
MAASLGQVLA LVLVAALWGG TQPLLKRASA GLQRVHEPTW AQQLLQEMKT LFLNTEYLMP
FLLNQCGSLL YYLTLASTDL TLAVPICNSL AIIFTLIVGK ALGEDIGGKR AVAGMVLTVI
GISLCITSSV PWTAELQLHG KGQLQTLSQK CKREASGTQS ERFG
