ID   TM235_MOUSE             Reviewed;         211 AA.
AC   B1AQL3;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 3.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Transmembrane protein 235;
DE   AltName: Full=Claudin-27;
DE   Flags: Precursor;
GN   Name=Tmem235; Synonyms=Cldn27, Gm12581;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   SUBCELLULAR LOCATION, AND GLYCOSYLATION.
RX   PubMed=21689651; DOI=10.1016/j.febslet.2011.05.060;
RA   Maher G.J., Hilton E.N., Urquhart J.E., Davidson A.E., Spencer H.L.,
RA   Black G.C., Manson F.D.;
RT   "The cataract-associated protein TMEM114, and TMEM235, are glycosylated
RT   transmembrane proteins that are distinct from claudin family members.";
RL   FEBS Lett. 585:2187-2192(2011).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Endoplasmic reticulum
CC       {ECO:0000305|PubMed:21689651}.
CC   -!- PTM: N-glycosylated. {ECO:0000269|PubMed:21689651}.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. {ECO:0000305}.
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DR   EMBL; AL591433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS36383.1; -.
DR   RefSeq; NP_001079004.1; NM_001085535.1.
DR   AlphaFoldDB; B1AQL3; -.
DR   SMR; B1AQL3; -.
DR   STRING; 10090.ENSMUSP00000091432; -.
DR   PaxDb; B1AQL3; -.
DR   PRIDE; B1AQL3; -.
DR   Antibodypedia; 64790; 5 antibodies from 5 providers.
DR   Ensembl; ENSMUST00000093905; ENSMUSP00000091432; ENSMUSG00000070330.
DR   GeneID; 546519; -.
DR   KEGG; mmu:546519; -.
DR   UCSC; uc007mof.1; mouse.
DR   CTD; 283999; -.
DR   MGI; MGI:3651706; Tmem235.
DR   VEuPathDB; HostDB:ENSMUSG00000070330; -.
DR   eggNOG; ENOG502S049; Eukaryota.
DR   GeneTree; ENSGT00390000011615; -.
DR   HOGENOM; CLU_102991_0_0_1; -.
DR   InParanoid; B1AQL3; -.
DR   OMA; LWRTCEG; -.
DR   OrthoDB; 1265742at2759; -.
DR   PhylomeDB; B1AQL3; -.
DR   TreeFam; TF327980; -.
DR   BioGRID-ORCS; 546519; 5 hits in 72 CRISPR screens.
DR   PRO; PR:B1AQL3; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; B1AQL3; protein.
DR   Bgee; ENSMUSG00000070330; Expressed in spermatocyte and 3 other tissues.
DR   GO; GO:0016324; C:apical plasma membrane; IDA:MGI.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR039951; TMEM114/TMEM235.
DR   PANTHER; PTHR20516; PTHR20516; 1.
DR   Pfam; PF13903; Claudin_2; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..211
FT                   /note="Transmembrane protein 235"
FT                   /id="PRO_0000406903"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   211 AA;  21957 MW;  26BB9DD9FB7843CA CRC64;
     MALLATLLLS AALGALLSFA LLAAAVASDY WYILEVADAG GLGGVQLFSH SGLWRTCEGQ
     NSCVPLIDPF ASAGLEVSPS VQHLLSLHRT VMVVLPLSLV LIVCGWVCGL LSSLSQSVPL
     LLATGCYFLL GGALTLAGLS IYISYSHLAF VEAARTYGVT HVQNVHISFG WSLALAWASC
     ASEVLSGALL LAAARLLSLS QRPGVPHSVI L