ID   TM236_DANRE             Reviewed;         350 AA.
AC   A5WVU6;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Transmembrane protein 236;
GN   Name=tmem236; ORFNames=si:dkey-32m20.1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM236 family. {ECO:0000305}.
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DR   EMBL; CT027716; CAN88071.1; -; Genomic_DNA.
DR   RefSeq; NP_001093549.1; NM_001100079.1.
DR   AlphaFoldDB; A5WVU6; -.
DR   STRING; 7955.ENSDARP00000101648; -.
DR   PaxDb; A5WVU6; -.
DR   Ensembl; ENSDART00000136360; ENSDARP00000116369; ENSDARG00000075715.
DR   GeneID; 100002496; -.
DR   KEGG; dre:100002496; -.
DR   CTD; 653567; -.
DR   eggNOG; ENOG502QVFM; Eukaryota.
DR   GeneTree; ENSGT00390000015525; -.
DR   HOGENOM; CLU_072609_0_0_1; -.
DR   InParanoid; A5WVU6; -.
DR   OMA; FFIIRVA; -.
DR   OrthoDB; 667499at2759; -.
DR   PhylomeDB; A5WVU6; -.
DR   PRO; PR:A5WVU6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 2.
DR   Bgee; ENSDARG00000075715; Expressed in intestine and 5 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR020394; Uncharacterised_FAM23-like_TM.
DR   PANTHER; PTHR31453; PTHR31453; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..350
FT                   /note="Transmembrane protein 236"
FT                   /id="PRO_0000409539"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        259..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   350 AA;  39208 MW;  2F29E64F9DFF3EF7 CRC64;
     MLSGKTVKLI VFELLQFACL CIPVFVVMER FASVIRFVKS SDTAYWLVVA ASVAYAASVT
     LFVWVPLKYF MLKTQRFSEV TNWRPVTLAY VILSTLPCFA IIIASSKVQA DAAIRFDRLT
     ELPVSLVLFS LICVDIVERI RPLRLTGKAS GLDLDLEMPG PVLTHLEQVT SISGHLQANG
     QDGDASFRSP VSNGSLSGRW EDARTYGLPR TSSSAYLYSH SHSGPFSFLW KRDPRHDLFV
     SSFMFWLDTV EMVRVAGTNS VFYSGWVFPI YILAYLSLLR VVITPDSPLL ALSSILSQDL
     PFLVVRICLL AVFGYVTPVL YILKNILASI SFVYFVFMTK LKLLNRGSMF