TM236_HUMAN
ID TM236_HUMAN Reviewed; 351 AA.
AC Q5W0B7; B2RXH7;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Transmembrane protein 236;
GN Name=TMEM236; Synonyms=FAM23A, FAM23B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5W0B7; P41181: AQP2; NbExp=3; IntAct=EBI-13378608, EBI-12701138;
CC Q5W0B7; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-13378608, EBI-18304435;
CC Q5W0B7; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-13378608, EBI-13345167;
CC Q5W0B7; P35372-10: OPRM1; NbExp=3; IntAct=EBI-13378608, EBI-12807478;
CC Q5W0B7; Q7Z7N9: TMEM179B; NbExp=3; IntAct=EBI-13378608, EBI-11724423;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM236 family. {ECO:0000305}.
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DR EMBL; AL139238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC157856; AAI57857.1; -; mRNA.
DR CCDS; CCDS41492.1; -.
DR RefSeq; NP_001092314.1; NM_001098844.2.
DR AlphaFoldDB; Q5W0B7; -.
DR BioGRID; 575888; 6.
DR IntAct; Q5W0B7; 6.
DR STRING; 9606.ENSP00000366715; -.
DR GlyGen; Q5W0B7; 1 site.
DR iPTMnet; Q5W0B7; -.
DR PhosphoSitePlus; Q5W0B7; -.
DR BioMuta; TMEM236; -.
DR DMDM; 73620896; -.
DR MassIVE; Q5W0B7; -.
DR PaxDb; Q5W0B7; -.
DR PeptideAtlas; Q5W0B7; -.
DR PRIDE; Q5W0B7; -.
DR ProteomicsDB; 65759; -.
DR Antibodypedia; 68395; 32 antibodies from 8 providers.
DR DNASU; 653567; -.
DR Ensembl; ENST00000377495.2; ENSP00000366715.1; ENSG00000148483.9.
DR GeneID; 653567; -.
DR KEGG; hsa:653567; -.
DR MANE-Select; ENST00000377495.2; ENSP00000366715.1; NM_001098844.3; NP_001092314.1.
DR UCSC; uc009xjx.5; human.
DR CTD; 653567; -.
DR GeneCards; TMEM236; -.
DR HGNC; HGNC:23473; TMEM236.
DR HPA; ENSG00000148483; Tissue enriched (intestine).
DR neXtProt; NX_Q5W0B7; -.
DR OpenTargets; ENSG00000148483; -.
DR PharmGKB; PA134931867; -.
DR VEuPathDB; HostDB:ENSG00000148483; -.
DR eggNOG; ENOG502QVFM; Eukaryota.
DR GeneTree; ENSGT00390000015525; -.
DR HOGENOM; CLU_072609_0_0_1; -.
DR InParanoid; Q5W0B7; -.
DR OMA; RTHYWLI; -.
DR OrthoDB; 667499at2759; -.
DR PhylomeDB; Q5W0B7; -.
DR TreeFam; TF328759; -.
DR PathwayCommons; Q5W0B7; -.
DR SignaLink; Q5W0B7; -.
DR BioGRID-ORCS; 653567; 14 hits in 1019 CRISPR screens.
DR ChiTaRS; TMEM236; human.
DR GenomeRNAi; 653567; -.
DR Pharos; Q5W0B7; Tdark.
DR PRO; PR:Q5W0B7; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q5W0B7; protein.
DR Bgee; ENSG00000148483; Expressed in duodenum and 68 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR020394; Uncharacterised_FAM23-like_TM.
DR PANTHER; PTHR31453; PTHR31453; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..351
FT /note="Transmembrane protein 236"
FT /id="PRO_0000186716"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 177..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 193
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 351 AA; 39663 MW; 9DE0E117BE24D76C CRC64;
MASGRLIKFV VFELLEFAAF SIPTLVITEQ FATAYQGTRA RSDNTHYWLI ISCSIAYVAL
VTLLIWVPVK VILHKKRYIY RKIKGWRPVL MMCVVLTTLP CLTFSIAVTE VQKSINGSAD
VLPDMLPDLP VSLVLLSLIM VDIIEKLRIY PLRGSQKSSE NGHIHSTSLQ HIKTVTEQVR
QSPENAASPQ ATNSTQVSQP SGAMTRSQES VFMGPQEPSC DSGILRMMSR RDVRAELFLW
SFLLWSDTIE MVRVAGHPNV YKSSWLYPVY IFSFISLLRI TFTPQNPLLN SLSVLLQDLP
FVFVRLGLII ALGTITPVLG LCKNILVTLS YIYFNYLTRI RIFSAFEMSP F
