ID   TM236_MOUSE             Reviewed;         344 AA.
AC   A2ARJ3;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Transmembrane protein 236;
GN   Name=Tmem236; Synonyms=Fam23a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM236 family. {ECO:0000305}.
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DR   EMBL; AL845434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS38049.1; -.
DR   RefSeq; NP_001074779.1; NM_001081310.2.
DR   AlphaFoldDB; A2ARJ3; -.
DR   STRING; 10090.ENSMUSP00000076722; -.
DR   GlyGen; A2ARJ3; 1 site.
DR   PhosphoSitePlus; A2ARJ3; -.
DR   PaxDb; A2ARJ3; -.
DR   PeptideAtlas; A2ARJ3; -.
DR   PRIDE; A2ARJ3; -.
DR   ProteomicsDB; 258927; -.
DR   Antibodypedia; 68395; 32 antibodies from 8 providers.
DR   Ensembl; ENSMUST00000077517; ENSMUSP00000076722; ENSMUSG00000061531.
DR   GeneID; 625286; -.
DR   KEGG; mmu:625286; -.
DR   UCSC; uc008ikj.1; mouse.
DR   CTD; 653567; -.
DR   MGI; MGI:1919309; Tmem236.
DR   VEuPathDB; HostDB:ENSMUSG00000061531; -.
DR   eggNOG; ENOG502QVFM; Eukaryota.
DR   GeneTree; ENSGT00390000015525; -.
DR   HOGENOM; CLU_072609_0_0_1; -.
DR   InParanoid; A2ARJ3; -.
DR   OMA; RTHYWLI; -.
DR   OrthoDB; 667499at2759; -.
DR   PhylomeDB; A2ARJ3; -.
DR   TreeFam; TF328759; -.
DR   BioGRID-ORCS; 625286; 0 hits in 69 CRISPR screens.
DR   ChiTaRS; Tmem236; mouse.
DR   PRO; PR:A2ARJ3; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; A2ARJ3; protein.
DR   Bgee; ENSMUSG00000061531; Expressed in small intestine Peyer's patch and 24 other tissues.
DR   Genevisible; A2ARJ3; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR020394; Uncharacterised_FAM23-like_TM.
DR   PANTHER; PTHR31453; PTHR31453; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..344
FT                   /note="Transmembrane protein 236"
FT                   /id="PRO_0000409538"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        114
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   344 AA;  38680 MW;  240DE545809D179E CRC64;
     MASGKIIKLV VFELLEFAAF SIPTLVIMEQ FATANQRTKS ERTHYWLIVS CSIAYVAVVS
     LLIWVPVKVV LYKKRHLYKK IIGWRPVLVM CVVLTTLPSF SFSIAVTEVQ KNINGSANSL
     PESLPDLPVS LVLLSLIVVD IIEKLRQYPL RGSQKGYEDN DICITSLQQI KTVTEQVVQS
     DGNPASAQAA KPTAMSQPRN HVAVLAGPLE PSFQSRILRT MSQRDVRAEL FLRSFLMWAD
     TVEMLRVAGH QAVYKSAWLY PVYIFSFISL LRMVFTPKNP LLNSLGILMQ DLPFVFLRLS
     LILALGTITP VLGLCKNVLV TISYIYFNYV TKLRPFSAFE TSPF