ID   TM237_CAEEL             Reviewed;         399 AA.
AC   Q20687;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 2.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Transmembrane protein 237 homolog;
DE   AltName: Full=Joubert syndrome 14 protein homolog {ECO:0000312|WormBase:F53A9.4};
GN   Name=jbts-14 {ECO:0000312|WormBase:F53A9.4};
GN   Synonyms=tmem-237 {ECO:0000250|UniProtKB:Q96Q45};
GN   ORFNames=F53A9.4 {ECO:0000312|WormBase:F53A9.4};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=22152675; DOI=10.1016/j.ajhg.2011.11.005;
RA   Huang L., Szymanska K., Jensen V.L., Janecke A.R., Innes A.M., Davis E.E.,
RA   Frosk P., Li C., Willer J.R., Chodirker B.N., Greenberg C.R., McLeod D.R.,
RA   Bernier F.P., Chudley A.E., Muller T., Shboul M., Logan C.V., Loucks C.M.,
RA   Beaulieu C.L., Bowie R.V., Bell S.M., Adkins J., Zuniga F.I., Ross K.D.,
RA   Wang J., Ban M.R., Becker C., Nurnberg P., Douglas S., Craft C.M.,
RA   Akimenko M.A., Hegele R.A., Ober C., Utermann G., Bolz H.J., Bulman D.E.,
RA   Katsanis N., Blacque O.E., Doherty D., Parboosingh J.S., Leroux M.R.,
RA   Johnson C.A., Boycott K.M.;
RT   "TMEM237 is mutated in individuals with a Joubert syndrome related disorder
RT   and expands the role of the TMEM family at the ciliary transition zone.";
RL   Am. J. Hum. Genet. 89:713-730(2011).
CC   -!- FUNCTION: Component of the transition zone in primary cilia. Required
CC       for ciliogenesis. {ECO:0000269|PubMed:22152675}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Cell projection, cilium
CC       {ECO:0000269|PubMed:22152675}. Note=Localizes the transition zone.
CC   -!- SIMILARITY: Belongs to the TMEM237 family. {ECO:0000305}.
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DR   EMBL; FO081048; CCD68803.1; -; Genomic_DNA.
DR   PIR; T16433; T16433.
DR   RefSeq; NP_509471.2; NM_077070.4.
DR   AlphaFoldDB; Q20687; -.
DR   STRING; 6239.F53A9.4; -.
DR   TCDB; 8.A.121.1.5; the transmembrane protein 237 (tmem237) family.
DR   EPD; Q20687; -.
DR   PaxDb; Q20687; -.
DR   EnsemblMetazoa; F53A9.4.1; F53A9.4.1; WBGene00018727.
DR   GeneID; 181116; -.
DR   KEGG; cel:CELE_F53A9.4; -.
DR   UCSC; F53A9.4; c. elegans.
DR   CTD; 181116; -.
DR   WormBase; F53A9.4; CE30141; WBGene00018727; jbts-14.
DR   eggNOG; ENOG502SDR2; Eukaryota.
DR   HOGENOM; CLU_691244_0_0_1; -.
DR   InParanoid; Q20687; -.
DR   OMA; CIQLESQ; -.
DR   OrthoDB; 1174719at2759; -.
DR   PhylomeDB; Q20687; -.
DR   PRO; PR:Q20687; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00018727; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0036064; C:ciliary basal body; IDA:UniProtKB.
DR   GO; GO:0035869; C:ciliary transition zone; IDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; IMP:UniProtKB.
DR   GO; GO:1905515; P:non-motile cilium assembly; IGI:WormBase.
DR   InterPro; IPR029409; TMEM237.
DR   PANTHER; PTHR28388; PTHR28388; 1.
DR   Pfam; PF15383; TMEM237; 1.
PE   3: Inferred from homology;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..399
FT                   /note="Transmembrane protein 237 homolog"
FT                   /id="PRO_0000415835"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..67
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..86
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..135
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..158
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   399 AA;  45587 MW;  F36E8D752C3BB9E8 CRC64;
     MPPTSRPVPP PPKRRISESS SSSDDELTGN NSFRENQQRR FRENNEVGNI SDSDNDEVFS
     HQESQSVGFI ETDEERQREE HAQNSNLRNR RVSYGKIPVP PMSMTVEDIQ EAAKHSREDP
     SGETVEVRRP NDPRRSSVSL DVFKSFRDPH DKRNMPAKDK TIYVEGPNGK FREMKKGKFW
     NRDKFDSPKK DAEKKQDEDS VIPFLLKAPG QAYRTQRVYN QIANIIQGFL AGISVMLAIF
     SFNLEPEVLL TGYRYMSLPI HAGFMVAFTV GLVSAIDRTG IYEVEHFTSR TRLTATVYNN
     GLITFIVWFV GLVSTLLCIQ LESQLAFAPT RIPSEDLVHH WRVFNVLRAL TSGLGFLLLA
     FKPDSDTMAK ELREAIYEQL ELVTSDPERR RVIITAMKI