ID   TM237_XENLA             Reviewed;         389 AA.
AC   A9ULX8;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Transmembrane protein 237;
GN   Name=tmem237;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the transition zone in primary cilia. Required
CC       for ciliogenesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Cell projection, cilium {ECO:0000250}.
CC       Note=Localizes to the transition zone. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM237 family. {ECO:0000305}.
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DR   EMBL; BC157443; AAI57444.1; -; mRNA.
DR   RefSeq; NP_001108263.1; NM_001114791.1.
DR   AlphaFoldDB; A9ULX8; -.
DR   GeneID; 100137642; -.
DR   KEGG; xla:100137642; -.
DR   CTD; 100137642; -.
DR   Xenbase; XB-GENE-1194182; tmem237.L.
DR   OrthoDB; 1428687at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 100137642; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0030111; P:regulation of Wnt signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR029409; TMEM237.
DR   PANTHER; PTHR28388; PTHR28388; 1.
DR   Pfam; PF15383; TMEM237; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..389
FT                   /note="Transmembrane protein 237"
FT                   /id="PRO_0000415833"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        284..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..97
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..116
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   389 AA;  43845 MW;  AC992CBE261BCCF5 CRC64;
     MGKKQVALPR ALPPMPSTSI DEIPHSRPKK KKTKSNNNTP DDVLQNAGFT TSENNDPLSP
     ERRKRKKKRF SIDAETSLTQ NNPSIPVVLN GKDTDNQTTE EGATRKPRRR TKKTRLAEEE
     FPNELGVEDE DIIPDGHTKI PTQNPAFLAS SLTSQPVGKL FVEKNRRFQA ADRSEIIKTT
     EQMDVFLDVK PTWSSMDVSL TAHHIFRMVG LFCCGFLAGY AVWNIVVIYV LAGSQLTNLP
     NLLQTYKILA YPSQCFLYFL LVLSTVTAFD RIDLERAADA LRGLLKLDPA AVASFFYFVA
     LFLVLSQQMT SDRMNFYTPP TQNGSLWQTD TEGQILQPWI VINLVVAILV GLAWLFLSCR
     PDIDHSEEAM FIPEEEDYPD MEKGMKIQG