ID   TM237_XENTR             Reviewed;         387 AA.
AC   F6UF99; F6VNI4;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Transmembrane protein 237;
GN   Name=tmem237;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
CC   -!- FUNCTION: Component of the transition zone in primary cilia. Required
CC       for ciliogenesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Cell projection, cilium {ECO:0000250}.
CC       Note=Localizes to the transition zone. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM237 family. {ECO:0000305}.
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DR   EMBL; AAMC01059190; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01059191; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01059192; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; F6UF99; -.
DR   PaxDb; F6UF99; -.
DR   eggNOG; ENOG502QTW0; Eukaryota.
DR   HOGENOM; CLU_061097_0_0_1; -.
DR   InParanoid; F6UF99; -.
DR   OMA; THCACAR; -.
DR   TreeFam; TF329703; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0030111; P:regulation of Wnt signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR029409; TMEM237.
DR   PANTHER; PTHR28388; PTHR28388; 1.
DR   Pfam; PF15383; TMEM237; 1.
PE   3: Inferred from homology;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..387
FT                   /note="Transmembrane protein 237"
FT                   /id="PRO_0000415834"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..95
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   387 AA;  43469 MW;  12DD6C2C842958BF CRC64;
     MGKKQVAPPR ALPPMPSLKD EIPLSRSKKK KSKSNNVPDD LLQNAGFNTS ENKDPLSPER
     RKKKKKRLSI DAETSLTQHN PALPVVQNGK DTDNQAAEEG TTRKPRRRTK KTRSVGQEFP
     NELGVEDEDI IPDGHTKIPE QNPAFLASSL TSQPVGKFFV EKNRRFQAAD RSEIIKTTEQ
     TDVFLDVKPT WTSMDVSLTA HHIFRMVGLF CCGFLAGYAV WNIVVVYVLA GSQLTNLPNL
     LQTYKILAYP SQCFLYFLLV LSTITAFDRI DLERTADALR GLLKLDPAAL ASFFYFVALI
     LALSQQMTSD RINFYTPPTE NGSLWQANTE EQILQPWIVI NLVVALLVGL AWLFLSCRPD
     IDHTEEAMFI PEGEDYPDME KGTKIQG