TM238_HUMAN
ID TM238_HUMAN Reviewed; 176 AA.
AC C9JI98;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Transmembrane protein 238;
GN Name=TMEM238;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-176.
RC TISSUE=Mammary carcinoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AC020922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC052596; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS54323.1; -.
DR RefSeq; NP_001177693.1; NM_001190764.1.
DR AlphaFoldDB; C9JI98; -.
DR BioGRID; 132746; 3.
DR STRING; 9606.ENSP00000416154; -.
DR iPTMnet; C9JI98; -.
DR PhosphoSitePlus; C9JI98; -.
DR BioMuta; TMEM238; -.
DR EPD; C9JI98; -.
DR jPOST; C9JI98; -.
DR MassIVE; C9JI98; -.
DR MaxQB; C9JI98; -.
DR PaxDb; C9JI98; -.
DR PeptideAtlas; C9JI98; -.
DR PRIDE; C9JI98; -.
DR ProteomicsDB; 10307; -.
DR DNASU; 388564; -.
DR Ensembl; ENST00000444469.4; ENSP00000416154.2; ENSG00000233493.4.
DR GeneID; 388564; -.
DR KEGG; hsa:388564; -.
DR MANE-Select; ENST00000444469.4; ENSP00000416154.2; NM_001190764.2; NP_001177693.1.
DR UCSC; uc002qku.4; human.
DR CTD; 388564; -.
DR GeneCards; TMEM238; -.
DR HGNC; HGNC:40042; TMEM238.
DR HPA; ENSG00000233493; Tissue enhanced (intestine, stomach).
DR neXtProt; NX_C9JI98; -.
DR VEuPathDB; HostDB:ENSG00000233493; -.
DR eggNOG; ENOG502S3VR; Eukaryota.
DR GeneTree; ENSGT00940000162720; -.
DR HOGENOM; CLU_127999_0_0_1; -.
DR InParanoid; C9JI98; -.
DR OMA; GVEMPHT; -.
DR OrthoDB; 1635450at2759; -.
DR PhylomeDB; C9JI98; -.
DR TreeFam; TF339060; -.
DR PathwayCommons; C9JI98; -.
DR BioGRID-ORCS; 388564; 9 hits in 1067 CRISPR screens.
DR ChiTaRS; TMEM238; human.
DR Pharos; C9JI98; Tdark.
DR PRO; PR:C9JI98; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; C9JI98; protein.
DR Bgee; ENSG00000233493; Expressed in mucosa of transverse colon and 89 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029365; TMEM238.
DR PANTHER; PTHR28613; PTHR28613; 1.
DR Pfam; PF15125; TMEM238; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..176
FT /note="Transmembrane protein 238"
FT /id="PRO_0000413540"
FT TOPO_DOM 1..36
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..69
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..176
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 175
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT CONFLICT 14
FT /note="P -> S (in Ref. 2; BC052596)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 176 AA; 18040 MW; 323ABC220EC3506C CRC64;
MAAAPAVCAS QGSPPGAPSA PAAAPAPAAG LGRCRMALLL AVALDVAGMA ALLTGVFAQL
QVRGRDFGDL LIYSGALLVF LSLLGWILWY TGNIEISRQE LERDYGLRPS ALARLARKLS
RRWSAPAAAG QRPAPGSRRA RRAARAPPPP AAGSRRVRLQ LATLEAGPGA AGAGSE
