ID   TM238_MOUSE             Reviewed;         176 AA.
AC   A9JSM3;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Transmembrane protein 238;
GN   Name=Tmem238;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC162034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC132101; AAI32102.1; -; mRNA.
DR   EMBL; BC144965; AAI44966.1; -; mRNA.
DR   CCDS; CCDS51977.1; -.
DR   RefSeq; NP_083660.1; NM_029384.1.
DR   AlphaFoldDB; A9JSM3; -.
DR   STRING; 10090.ENSMUSP00000130452; -.
DR   iPTMnet; A9JSM3; -.
DR   PhosphoSitePlus; A9JSM3; -.
DR   EPD; A9JSM3; -.
DR   MaxQB; A9JSM3; -.
DR   PaxDb; A9JSM3; -.
DR   PRIDE; A9JSM3; -.
DR   ProteomicsDB; 259412; -.
DR   Ensembl; ENSMUST00000168578; ENSMUSP00000130452; ENSMUSG00000030431.
DR   GeneID; 664968; -.
DR   KEGG; mmu:664968; -.
DR   UCSC; uc009eyr.1; mouse.
DR   CTD; 388564; -.
DR   MGI; MGI:1922935; Tmem238.
DR   VEuPathDB; HostDB:ENSMUSG00000030431; -.
DR   eggNOG; ENOG502S3VR; Eukaryota.
DR   GeneTree; ENSGT00940000162720; -.
DR   HOGENOM; CLU_127999_0_0_1; -.
DR   InParanoid; A9JSM3; -.
DR   OMA; GVEMPHT; -.
DR   OrthoDB; 1529811at2759; -.
DR   PhylomeDB; A9JSM3; -.
DR   TreeFam; TF339060; -.
DR   BioGRID-ORCS; 664968; 1 hit in 71 CRISPR screens.
DR   ChiTaRS; Tmem238; mouse.
DR   PRO; PR:A9JSM3; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; A9JSM3; protein.
DR   Bgee; ENSMUSG00000030431; Expressed in epithelium of stomach and 124 other tissues.
DR   ExpressionAtlas; A9JSM3; baseline and differential.
DR   Genevisible; A9JSM3; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR029365; TMEM238.
DR   PANTHER; PTHR28613; PTHR28613; 1.
DR   Pfam; PF15125; TMEM238; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..176
FT                   /note="Transmembrane protein 238"
FT                   /id="PRO_0000413541"
FT   TOPO_DOM        1..36
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        58..69
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        91..176
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          124..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         175
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:C9JI98"
SQ   SEQUENCE   176 AA;  18226 MW;  2C5D6464FBAF5FD0 CRC64;
     MAAASPVCGS QASAVGASSP PAPAPAPAAG LGRCRMALLL AVALDVAGMA ALLTGVFAQL
     QVRGRDFGDL LIYSGALLVF LSLLGWILWY TGNIEISRQE LERDYGLRPS AIARLARKLS
     RRWSAPATAS PRTTAGLRSA RRANRAPQPS SSGSRRVRLQ LATLEAGSVA AGTGSE